Alveolar Soft Part Sarcoma Occurring on the Abdominal Wall of a 2-year-old Child

Jia, Ying; Wu, Di; Shang, Cong; Yu, Jing; Zhang, Ke Ren

doi:10.1097/mph.0b013e3181fb7cbd

Cited by 6 publications

(5 citation statements)

References 1 publication

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“…According to previous studies, the patient's age, tumour size and presence of metastases at diagnosis are significant prognostic factors in ASPS. It is hypothesized that younger age with a tumour size of <5 cm and absence of metastases is associated with a more favourable outcome ( 48 , 59 ). If the tumour is resected completely, younger patients may achieve a good prognosis with prolonged survival rates ( 40 , 60 ).…”

Section: Prognosismentioning

confidence: 99%

Orbital alveolar soft part sarcoma: A report of 8ï¿½cases and review of the literature

Huang

Yang

et al. 2017

Oncol Lett

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Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm. The incidence of orbital involvement is the highest in ASPS arising in the head and neck region. However, limited information is available regarding its clinical characteristics. The present study presents the clinical manifestations, imaging findings, pathological features, treatment strategies and prognosis records of 8 cases of orbital ASPS over the last 15 years in a single hospital, along with a review of the literature. Included were 3 male and 5 female patients, with the median age at presentation being 9.5 years. The mean average largest tumour diameter was 3.6 cm. A total of 5 patients underwent surgical excision of the tumour, with 2 undergoing orbital exenteration and 1 undergoing partial orbital exenteration. In total, 6 patients received postoperative radiotherapy and 2 received chemotherapy. Upon follow-up, 6 patients were doing well with no evidence of recurrence or metastasis. Local recurrence developed in 2 patients, of whom 1 succumbed following withdrawal from treatment. According to the present series and the cases mentioned in the literature, orbital alveolar soft part sarcoma has characteristics distinct from those of alveolar soft part sarcoma which arises in other locations. Orbital alveolar soft part sarcoma presents itself in a younger population with a shorter course of disease, smaller tumour size, improved prognosis, a marked association with the extraocular muscles and with the Ki-67 proliferation index possibly associated with prognosis of the disease.

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Section: Prognosismentioning

confidence: 99%

Orbital alveolar soft part sarcoma: A report of 8ï¿½cases and review of the literature

Huang

Yang

et al. 2017

Oncol Lett

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“…Approximately 40% arise in the deep soft tissues of the thigh and buttock; other frequent sites include skeletal muscle and musculofascial planes of the extremities, abdomen, or chest wall [89]. Unusual sites, especially in children, include the head and neck region, orbit, tongue, bone, female genital tract, and gastrointestinal tract [84,[90][91][92][93][94][95][96][97]. Twenty percent of patients have metastases at the time of initial diagnosis [85][86][87].…”

Section: Tumors Of Uncertain Histogenesismentioning

confidence: 99%

Soft Tissue Tumors of Uncertain Origin

2012

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Many soft tissue tumors of childhood lack obvious differentiation toward a defined mesenchymal tissue type or have a phenotype that does not correspond to any defined normal tissue. These challenging tumors are currently regarded as neoplasms of uncertain differentiation. Nonetheless, there have been great strides in the understanding of their pathologic and genetic features and biologic underpinnings. The application of new genetic information to the pathologic diagnosis among this group of tumors is an emerging area in diagnostic pediatric pathology. This article reviews the clinicopathologic features of tumors of uncertain and/or miscellaneous origin, with an emphasis on the unique aspects of these neoplasms in children and adolescents, use of diagnostic adjuncts, and differential diagnosis.

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“…Crystals are aggregates of monocarboxylic acid transporter MCT1 and its cellular chaperone CD147, which can be found in 80% of tumors. Almost all of them had vascular infiltration (9,13,23).…”

Section: Discussionmentioning

confidence: 99%

Alveolar soft part sarcoma in childhood and adolescence: Report of three cases and review of literature

Zhang

Wang

et al. 2022

Front. Pediatr.

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Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma with unique tumor characteristics, which is rare in children. Herein, we present the immunophenotype, treatment, and prognosis of three children with ASPS from The Second Xiangya Hospital of Central South University, and 51 children with ASPS have been reported in the previous literature, along with a focused review of the clinical features, pathological features, differential diagnosis, treatment, and prognosis of ASPS in pediatric patients.

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Alveolar Soft Part Sarcoma Occurring on the Abdominal Wall of a 2-year-old Child

Cited by 6 publications

References 1 publication

Orbital alveolar soft part sarcoma: A report of 8ï¿½cases and review of the literature

Orbital alveolar soft part sarcoma: A report of 8ï¿½cases and review of the literature

Soft Tissue Tumors of Uncertain Origin

Alveolar soft part sarcoma in childhood and adolescence: Report of three cases and review of literature

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