Alveolar soft part sarcoma in children and adolescents: A report from the Soft-Tissue Sarcoma Italian Cooperative Group

Casanova, Michela; Ferrari, Andrea; Bisogno, Gianni; Cecchetto, Giovanni; Basso, Eleonora; Bernardi, Bruno; Indolfi, Paolo; Ff, Bellani; Carli, Modesto

doi:10.1023/a:1026579623136

Cited by 136 publications

(185 citation statements)

References 12 publications

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“…We found age older than 75+ years independently predicted poor survival. Moreover, as reported by Casanova et al [7], we also found younger age did not predict improved survival.…”

Section: Discussionsupporting

confidence: 87%

“…This observation has been confirmed by others [7,8,39]. However, Ross et al [36] reported no association of primary tumor site with patient survival.…”

Section: Discussionsupporting

confidence: 56%

“…Previous reports describing the outcomes of patients with ES have limited statistical power owing to the small number of patients in each series [3][4][5][6][7]. The largest series to date by Chase and Enzinger [8] in 1985 described 241 patients from multiple centers.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Jawad

Extein²,

Min

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Current stratification of prognosis in patients with epithelioid sarcoma (ES) is based largely on data reported by individual centers with a limited number of patients. We sought to identify the important prognostic parameters using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 441 patients with ES in the database and extracted information regarding patient demographics and clinical characteristics. KaplanMeier, log-rank, and Cox regression were used for analysis.

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“…We found age older than 75+ years independently predicted poor survival. Moreover, as reported by Casanova et al [7], we also found younger age did not predict improved survival.…”

Section: Discussionsupporting

confidence: 87%

“…This observation has been confirmed by others [7,8,39]. However, Ross et al [36] reported no association of primary tumor site with patient survival.…”

Section: Discussionsupporting

confidence: 56%

See 1 more Smart Citation

Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Jawad

Extein²,

Min

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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“…Studies are underway to evaluate the utility of sentinel lymph node biopsy [28,29]. The indication for nodal biopsy in cases of NRSTS affecting the extremities is more controversial: some histotypes (i.e., epithelioid sarcoma, clear cell sarcoma, alveolar soft part sarcoma, and angiosarcoma) would appear to have a greater tendency than others to spread to regional lymph nodes, and biopsy may be indicated in such cases [21,27], though pediatric cases seem to have a weaker propensity for nodal spread than in their adult counterpart (particularly for epithelioid sarcoma [30]) so further studies are needed to clarify this matter. Of course, good coordination between surgeon, pediatric oncologist, pathologist, and radiotherapist is mandatory to plan a successful multimodality treatment for these patients, and the pediatric oncology team should also consider procedures such as regional arterial perfusion [31,32] or intraoperative brachytherapy, which are generally used more for adult STS of the extremities but may have a role in some specific pediatric cases.…”

Section: Discussionmentioning

confidence: 99%

Soft-tissue sarcomas of the extremities in patients of pediatric age

Casanova

Meazza

Gronchi

et al. 2007

Journal of Children's Orthopaedics

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Purpose The extremity site is a peculiar location for softtissue sarcomas (STS) of children and adolescents. Here we report the experience of the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, Italy, concerning 204 patients with STS of the limbs treated between 1977 and 2006. Methods The study series included 52 patients with rhabdomyosarcoma (RMS)(65% of which were of the alveolar subtype), nine with extraosseous Ewing sarcoma and 143 with non-rhabdomyosarcoma soft-tissue sarcomas (NRSTS), 38% of which were synovial sarcoma. Patients were treated with a multimodality approach including surgery, chemotherapy, and radiotherapy. Results For the RMS patients, the 5-year event-free survival (EFS) rate was 37.1%, with distant metastases being the main cause of treatment failure. The outcome was particularly poor for patients with large invasive tumors, hand/foot involvement and/or nodal or distant metastases, and for patients who were not given radiotherapy. For the extraosseous Ewing sarcoma cases, 5-year EFS was 74%. For the NRSTS cases, the 5-year EFS was 72.6%: tumor size and local invasiveness, tumor grade, malignant peripheral nerve sheath tumor (MPNST) histology, and distant metastases were the main prognostic factors. Discussion While the limbs are the most common sites of NRSTS and are often characterized by a more favorable prognosis than for axial tumors, the clinical features of extremity RMS often differ from those of RMS of other sites, with a higher incidence of unfavorable prognostic factors (e.g., alveolar subtype) and consequently unsatisfactory treatment results. The treatment of these patients is complex and necessarily multidisciplinary, and it demands not only adequate experience of treating children and adolescents in clinical trials, but also particular skills in the field of orthopedic surgery.

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“…The ultimate prognosis is still poor. There is only a partial response on chemotherapy in various combinations, in about 30% (Casanova et al, 2000;van Ruth et al, 2002).…”

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confidence: 99%