Abstract:Alveolar rhabdomyosarcoma (RMS) is extremely rare in adults older than 45 years and may be very difficult to distinguish from other primitive round cell neoplasms without immunohistochemistry and/or genetic studies. In adults, the differential diagnosis of small round cell tumors of the head and neck region includes small cell carcinoma, lymphomas and neuroepithelial tumors, such as esthesioneuroblastoma and, as last choice, rhabdomyosarcoma. Initial immunoprofiling may not include myogenic markers. Moreover, … Show more
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