Alveolar nitric oxide and asthma control in mild untreated asthma

The Heterogeneity Hidden in Allergic Rhinitis and Its Impact on Co-Existing Asthma in Adults: A Population-Based Survey

“…This may be due to poor adherence to the asthma therapy, which is very common in patients with AR only and mild asthma [30]. Furthermore, this seems to be consistent with recent studies on the presence of mast cells at the alveolar level in subjects with AR and uncontrolled asthma [31,32,33]. …”

Poor Symptom Control Is Associated With Reduced CT Scan Segmental Airway Lumen Area in Smokers With Asthma

“…[21][22][23][24][25][26] In the current study, we found that the fi ndings of tests thought to refl ect small airway function, including measurement of FEF 25%-75% and RV/TLC %, were worse in smokers with asthma compared with never smokers with asthma, suggesting a greater degree of small airway dysfunction, particularly in the severe smoking group. Tests of global lung function (FEV 1 /FVC), as well as small airway function, in the smoking group were signifi cantly associated with worse asthma symptoms, although lung function was not signifi cantly diff erent in patients with uncontrolled asthma with a diff erent smoking status.…”

“…20 Dysfunction of the small airways (defi ned as airways with an internal diameter , 2 mm) is associated with poor current asthma control in nonsmokers with asthma. [21][22][23][24][25][26] Th e combined eff ects of asthma and cigarette smoke could contribute to poor symptom control and an impaired response to treatment, at least in part as a result of dysfunction of the segmental and/or small airways. We wished to test the hypothesis that impaired symptom control in smokers with asthma compared with never smokers with asthma is associated with narrowed segmental airways, increased wall thickness, or both as measured by CT scan dimensions and/or is associated with abnormal tests of small airway function.…”

Clinically relevant outcome measures for new therapies of asthma using pharmaceutical and biologic agents

“…Nelson et al [34] used FEF and the closing volume over FVC to assess the effects of mometasone on small airways. Furthermore, Scichilone et al [35] found that mild untreated individuals with asthma on extrafine ICS therapy, thought to be more likely to reach the more peripheral airways, had a significant improvement in the Asthma Control Test score, in correlation with baseline higher alveolar fraction of exhaled nitric oxide (CalvNO) levels.…”