Alveolar Macrophages Secretory Dysfunctions in Coal Workers’s Pneumoconiosis. Comparison Between Simple Pneumoconiosis and Progressive Massive Fibrosis.

Lassalle, Philippe; Gosset, P.; Aerts, C; Benhamou, Marc; F, Fortin; Wallaert, B.; Tonnel, A.-B.; Voisin, C

doi:10.1007/978-3-642-74203-3_9

Cited by 6 publications

(2 citation statements)

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“…In contrast, AMs from patients with coal workers' pneumoconiosis released increased amounts of TNF and IL-6, but not of IL-1 [24,52,53]. Moreover, when patients were divided into two groups, simple pneumoconiosis (SP) and progressive massive fibrosis (PMF), an increased secretion of TNF and IL-6 was observed in PMF patients compared to SP [52]. In our laboratory, we recently confirmed the presence of these proinflammatory cytokines, TNF and IL-6, in the lung of pneumoconiotic patients [54,55,56].…”

Section: Tnf Il-1 and Il-6mentioning

confidence: 92%

“…In silicosis, blood monocytes secrete exaggerated quantities of TNF and IL-1 when compared to controls [51]. In contrast, AMs from patients with coal workers' pneumoconiosis released increased amounts of TNF and IL-6, but not of IL-1 [24,52,53]. Moreover, when patients were divided into two groups, simple pneumoconiosis (SP) and progressive massive fibrosis (PMF), an increased secretion of TNF and IL-6 was observed in PMF patients compared to SP [52].…”

Section: Tnf Il-1 and Il-6mentioning

confidence: 99%

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Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis

Vanhée¹,

Gosset²,

Boitelle³

et al. 1995

Eur Respir J

143

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The alveolar macrophage (AM) is a critically important cell playing a prominent role in lung inflammation via the production of oxygen radicals, enzymes, arachidonic acid metabolites, and also a large panel of cytokines. Among interstitial lung disorders, silicosis and coal workers' pneumoconiosis (CWP) are the most widespread fibrotic lung diseases. Although their pathophysiology remains incompletely understood, several lines of evidence suggest the participation of cytokines produced by AMs at least in the initiation of the alveolitis. In vitro exposure of AMs (obtained from healthy subjects) to coal dust particles triggered a significant release of tumour necrosis factor (TNF) and interleukin-6, by comparison with titanium dioxide used as a biologically inert control dust. Moreover, it appeared that coal mine dust was more aggressive than similar concentrations of pure silica, suggesting that cytokine secretion induced by coal mine dust was not exclusively related to the presence of silica but resulted from a complex interaction between the different components. In silicosis and CWP, bronchoalveolar lavage showed a large influx of mononuclear phagocytes, with an increased spontaneous production of oxidants, fibronectin, neutrophil chemotactic factor, and also of interleukin-6 and TNF-alpha. This spontaneous cytokine release was associated with an increased cytokine messenger ribonucleic acid (mRNA) expression in the lungs of coal miners.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Tnf Il-1 and Il-6mentioning

confidence: 92%

Section: Tnf Il-1 and Il-6mentioning

confidence: 99%

Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis

Vanhée¹,

Gosset²,

Boitelle³

et al. 1995

Eur Respir J

143

View full text Add to dashboard Cite

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Coal Dust

Blackley,

Halldin,

Hall

et al. 2023

Patty's Toxicology

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Coal is an organic, combustible, rock‐like natural substance that occurs in various forms from hard and brittle anthracite to soft and friable lignite. Coal mine dust often contains silica and other minerals found within the coal seam or in the adjacent strata. In the United States and other countries, coal miners are at risk of developing chronic lung diseases caused by cumulative exposure to respirable coal mine dust. These diseases can lead to significant lung function impairment, disability, and premature death. Collectively known as “black lung,” they include a spectrum of interstitial lung diseases including coal workers' pneumoconiosis (CWP), mixed dust pneumoconiosis, and dust‐related diffuse fibrosis as well as chronic airway diseases including emphysema and chronic bronchitis. Since the late 1990s, the prevalence of CWP and its most severe form, progressive massive fibrosis, have increased in the United States, most notably in central Appalachia. Factors contributing to this resurgence might include thin‐seam coal mining and/or cutting rock to access coal seams, which likely exposes miners to respirable coal mine dust with a higher content of other hazardous dusts including silica and silicates. Many countries have occupational exposure limits for coal mine dust typically based on assessment of the mass of dust collected during a work shift.

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Coal

Attfield¹,

Castranova²,

Kuempel³

et al. 2001

Patty's Toxicology

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Coal is an organic, combustible, rock‐like natural substance that occurs in various forms from hard and brittle anthracite to soft and friable lignite. Coal is sometimes classified into two types: hard coal and soft coal. These terms do not, however, have a standardized meaning. One definition calls anthracite hard coal and places all other coal types in the soft coal category. A more common convention is that of Speight, in which anthracite and bituminous coals are termed hard coal and lignite and brown coal are classified as soft coal. Research on the health effects of coal has been heavily concentrated on the more common anthracite and bituminous types. There, the results have shown more of a gradient in toxicological effect across coal types rather than any clear‐cut divisions between types. Little research has been undertaken on lignite and other brown coals. This has prohibited drawing firm conclusions on its toxicity relative to its harder cousins. This lack of any obvious demarcation has led us to report on overall patterns of effect rather than to provide separate presentations by coal type. Where data are available, we draw attention to any findings especially relevant to any particular coal type. Coal varies considerably in composition and consists largely of carbon, hydrogen, and oxygen with smaller amounts of sulfur, nitrogen, trace elements, and metals. Coal originated from mostly organic material that was long ago buried by sediments. Heat and pressure converted the plant remains over geologic time to coal, the process thought to have led to peat, lignite, bituminous coal, and anthracite in turn. Coal, as extracted, contains many minerals in various proportions, including quartz, clays, carbonates, and sulfides. These minerals can be intrinsic to the coal, as in silica grains within the coal matrix, or may lie in pockets or layers. Although there are different methods for classifying coal—each developed for a specific geological or economic purpose—all tend to relate to the age of the coal. Older coals are purer, harder, more brittle, have less volatile matter, and have higher calorific value. They also contain higher amounts of fixed carbon. Fixed carbon is the basis of a commonly used classification index of coal—coal rank. High rank coals, such as anthracite, have the greatest amount of fixed carbon, whereas bituminous and subbituminous coals are defined as low rank. A rank‐based system devised by the American Society for Testing and Materials (ASTM) divides coal into four main subtypes: anthracite, bituminous, subbituminous, and lignite. Each subtype is further divided, using fixed carbon, moist Btu, or other factors. For example, the main anthracite group is divided into meta‐anthracite (98% or more fixed carbon), anthracite (92–98% fixed carbon), and semianthracite (80–92% fixed carbon). The lignite group is split into lignite and brown coal; the main distinction is whether the substance is consolidated (lignite) or not consolidated (brown coal). Exposure to “pure” coal, that is, the dust generated from processing washed and cleaned coal, is rare. Most occupational exposures are to coal mine dust, an entity with varying properties, that contains coal and also dust generated from the accidental or deliberate cutting of the rock strata adjacent to or within the coal seam. The rock strata can be formed of limestone, shale, clay, or sandstone and therefore can give rise to silica and other dusts, which mix with the coal dust to give coal mine dust exposures. Consequently, coal mine dust contains 30–40% of noncoal minerals, of which about 5–10% is typically silica. The major inorganic constituents of coal ash. Virtually all of the findings on health outcomes in humans are derived from studies of exposures to coal mine dust.

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Alveolar Macrophages Secretory Dysfunctions in Coal Workers’s Pneumoconiosis. Comparison Between Simple Pneumoconiosis and Progressive Massive Fibrosis.

Cited by 6 publications

References 8 publications

Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis

Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis

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