Alveolar macrophages of children suffering from recurrent infections of respiratory tract are less efficient in eliminating apoptotic neutrophils

Pryjma, J; Kaszuba-Zwoińska, Jolanta; Pawlik, Jennifer; Pogorzelski, A; Lis, Grzegorz; Baran, Jarosław; Zebrak, J

doi:10.1002/(sici)1099-0496(199903)27:3<167::aid-ppul3>3.0.co;2-d

Cited by 9 publications

(6 citation statements)

References 23 publications

(25 reference statements)

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“…In patients with ARDS, apoptotic neutrophils in bronchoalveolar lavage fluid are not abundantly identifiable morphologically but are present during the first few days of the initial onset of disease [35]. This phenomenon may be consistent with the prevailing concept that apoptotic neu- respiratory tract infections, and in an animal model of experimental smoke inhalation injury [26,43].…”

Section: Discussionsupporting

confidence: 71%

“…In patients with cystic fibrosis, Pseudornonas aeruginosa products have been reported to inhibit macrophage phagocytosis [36,37]. Moreover, the ability of alveolar macrophages to phagocytose apoptotic neutrophils was found to be significantly impaired in smoke inhalation injury, a condition associated with a high incidence of both bacterial pneumonia and adult respiratory distress syndrome (ARDS) [26], and in children suffering recurrent respiratory tract infections [43]. Other investigations have suggested that macrophages which had previously ingested apoptotic cells subsequently have impaired ingestion capacity [ 18].…”

Section: Introductionmentioning

confidence: 99%

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Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment

Liu

Lin

et al. 2003

J Biomed Sci

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Clearance of apoptotic neutrophils by alveolar macrophages plays an important role in the resolution phase of lung inflammation. If not cleared, apoptotic neutrophils are postulated to release histotoxic granular contents. Since numerous cellular proteins are degraded during apoptosis, we sought to determine whether functional serine proteinases are indeed released by apoptosing neutrophils in vitro. In a coculture system, eytokine-aetirated neutrophils induced detachment in the human epithelial cell line, A549. This process was CD18-and serine proteinase-dependent. Early apoptotic neutrophils induced significant detachment, but live, senescent, resting neutrophils and terminal, secondary necrotic neutro-C.Y.L. and Y.H.L contributed equally to the work on this project as first authors. phils had a different effect. This detachment process was CD18-independent but serine proteinase-dependent. Similarly, detachment occurred with primary human small airway epithelial cells. Notably, epithelial cell detachment correlated with the transition of early apoptotic neutrophils to secondary necrosis and with the accumulation of elastase in the supernatant. The membrane integrity of lung epithelial cells was damaged in advance of significant cell detachment. These observations suggest that not only live activated neutrophils but also apoptosing neutrophils can reveal functional elastase activities. Furthermore, the rapidity of the transition emphasizes the importance of the prompt clearance of apoptotic neutrophils before they progress to secondary necrosis at the site of lung inflammation.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment

Liu

Lin

et al. 2003

J Biomed Sci

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“…Even though phagocyte functions (especially macrophages) may play some roles in the defence against viruses 25 there is no evidence that they are important to control viral infections frequent in common paediatric RRI. Although many studies have pointed the attention on the role of phagocytosis in frequent infectious diseases, 26–28 a causative role of congenital and persistent disorder of phagocytic activity (for instance intracellular killing or leukocyte adhesion) has never been established in such frequent diseases, in contrast to several rare disorders such as chronic granulomatous disease (CGD), leukocyte adhesion deficiencies (LAD) and other more rare illnesses 29,30 . ROI production is strongly reduced in CGD and FAG is severely decreased in LAD1.…”

Section: Discussionmentioning

confidence: 99%

Recurrent respiratory infections and phagocytosis in childhood

Don

Fasoli

Gregorutti

et al. 2007

Pediatrics International

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“…Several selective immune alterations have been associated with RRI, such as defects of Fcc receptor IIIa (CD16) on natural killer cells and of interleukin receptor-associate kinase-4 (IRAK-4), reduction in IL-12 production, polymorphisms in CCR2, CCR5 and mannose-binding lectin genes, mutations in TLR4 encoding sequences and defective removal of apoptotic de Martino & Ballotti neutrophils by alveolar macrophages (32)(33)(34)(35)(36)(37)(38). These conditions are permanent primary immunodeficiencies associated with severe diseases (capsulate bacterial or herpetic infections) (38).…”

Section: Immunology Of Rrimentioning

confidence: 99%

The child with recurrent respiratory infections: normal or not?

Martino

Ballotti

2007

Pediatric Allergy Immunology

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Respiratory infections (RI) are one of the major complaints in children and adolescents, and represent a demanding challenge for the pediatrician. It has been estimated that at least 6% of Italian children younger than 6 yr of age present recurrent respiratory infections (RRI). Children with RRI are not affected by severe alterations of the immune system. RRI represent essentially the consequence of an increased exposure to infectious agents during the first years of life, when immune functions are still largely immature. Several social and environmental factors, such as day-care attendance, family size, air pollution, parental smoking, and home dampness, represent important risk factors for airway diseases and may contribute in various degrees to determine the incidence of RRI. The main problem for the pediatrician is to discriminate normal children with high RI frequency related to an augmented exposure to environmental risk factors from children affected by other underlying pathological conditions (immunological or not), predisposing to infectious diseases. When RRI diagnosis has been formulated, removal of environmental risk factors (i.e. precocious day-care attendance, smoking in the household) must first be suggested.

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Alveolar macrophages of children suffering from recurrent infections of respiratory tract are less efficient in eliminating apoptotic neutrophils

Cited by 9 publications

References 23 publications

Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment

Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment

Recurrent respiratory infections and phagocytosis in childhood

The child with recurrent respiratory infections: normal or not?

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