Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs.

Finley, N; Norlin, Andreas; Baines, Deborah L.; Folkesson, Hans G.

doi:10.1172/jci1478

Cited by 89 publications

(147 citation statements)

References 49 publications

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“…Studies in guinea pig showed that both ␣-ENaC mRNA expression and the sensitivity of lung liquid clearance to amiloride and to ␤-adrenoceptor blockade were highest shortly after birth and declined in parallel with endogenous plasma epinephrine concentration (30), providing further support for the key role of ␤-adrenoceptor activation of Na ϩ channels at birth. However, because ␣-ENaC mRNA expression rapidly increases after caesarean section in late gestation and at term in guinea pig lungs (4), it would appear that the upregulation of this particular Na ϩ channel subunit is not related to labor.…”

Section: Molecular Expression Of Key Transport Proteins During Develomentioning

confidence: 91%

Invited Review: Clearance of lung liquid during the perinatal period

Barker

Olver

2002

Journal of Applied Physiology

106

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Barker, Pierre M., and Richard E. Olver. Invited Review: Clearance of lung liquid during the perinatal period. J Appl Physiol 93: 1542-1548, 2002; 10.1152/japplphysiol.00092.2002.-At birth, the distal lung epithelium undergoes a profound phenotypic switch from secretion to absorption in the course of adaptation to air breathing. In this review, we describe the developmental regulation of key membrane transport proteins and the way in which epinephrine, oxygen, glucocorticoids, and thyroid hormones interact to bring about this crucial change in function. Evidence from molecular, transgenic, cell culture, and whole lung studies is presented, and the clinical consequences of the failure of the physiological mechanisms that underlie perinatal lung liquid absorption are discussed. lung liquid; sodium absorption; chloride secretion; epithelial sodium channel; cystic fibrosis transmembrane conductance regulator THE MECHANISMS RESPONSIBLE for lung liquid clearance during the neonatal period develop gradually during the latter part of the third trimester of pregnancy, but the phenotypic switch of the lung epithelium from net secretion to net absorption, triggered by events at birth, is sudden. Although lung liquid absorption at birth is "a performance without rehearsal," the lung may be called on for an encore in later life when these same mechanisms are activated to clear accumulated edema liquid.Many of the early studies of perinatal lung liquid clearance, which were mostly undertaken on the intact lungs of rabbits and sheep in the 1970s and 1980s, provided information in vivo on the time course and regulation of lung liquid clearance in a fully integrated physiological context. These data have been supported and augmented in the past decade by cloning of genes that regulate transepithelial ion transport [particularly the sodium pump (Na ϩ -K ϩ -ATPase) and the epithelial Na ϩ channel (ENaC)] and the use of molecular approaches that have uncovered information at a subcellular level.

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Section: Molecular Expression Of Key Transport Proteins During Develomentioning

confidence: 91%

Invited Review: Clearance of lung liquid during the perinatal period

Barker

Olver

2002

Journal of Applied Physiology

106

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“…IL-1␣ also improved postnatal lung function with increased surfactant pool size without eliciting systemic inflammatory responses in lambs (14, 47). We recently reported that IL-1␤ pretreatment of timed-pregnant guinea pigs induced fluid absorption in fetal lungs, sodium transporter protein, and ␤-adrenoceptor expression via hypothalamus-pituitary-adrenal gland axis stimulation (48).Lung fluid absorption occurs secondarily to transepithelial Na ϩ absorption (3,5,8,17,22,31,35,37,45,48,49) and is driven by basolateral Na-K-ATPases (16, 23) and apical epithelial sodium channels (19,22,30,31). Fluid absorption occurs in near-term lungs (6,17,35,37,45) and is induced/ stimulated by cortisol and triiodothyronine (2, 20, 48) and labor-released epinephrine (17,35,45).…”

mentioning

confidence: 99%

“…Fluid absorption occurs in near-term lungs (6,17,35,37,45) and is induced/ stimulated by cortisol and triiodothyronine (2,20,48) and labor-released epinephrine (17,35,45).…”

mentioning

confidence: 99%

“…In this study, we tested whether labor in itself additively stimulated IL-1␤-induced lung fluid absorption. Because labor-induced epinephrine release stimulates lung fluid absorption at birth in guinea pigs (17,35), our first aim was to investigate whether lung fluid absorption becomes more sensitive to endogenous ␤-adrenergic stimulation after the combined IL-1␤ and oxytocin treatments. A second aim was to study development of the fractional amiloride sensitivity of lung fluid absorption under normal conditions and after oxytocin induction of labor with and without IL-1␤.…”

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confidence: 99%

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Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Nair¹,

Li²,

Bhattacharjee³

et al. 2005

American Journal of Physiology-Lung Cellular and Molecular Phys

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-We tested the hypothesis that oxytocin-induced labor augmented IL-1␤-induced/ -stimulated lung fluid absorption in preterm guinea pig fetuses. IL-1␤ was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. At day 3, oxytocin was administered, and fetuses were delivered by abdominal hysterotomy at 61 and by oxytocin-induced birth at 68 days gestation. Delivered fetuses were instilled with isosmolar 5% albumin into the lungs, and lung fluid movement was measured over 1 h by mass balance. Lung fluid absorption was induced in 61-day and stimulated in 68-day gestation lungs by IL-1␤. Labor induction by oxytocin augmented IL-1␤-induced/-stimulated lung fluid absorption. Metyrapone pretreatment did not affect oxytocin-induced/-stimulated lung fluid absorption, while completely blocking IL-1␤-induced/-stimulated fluid absorption. Fetal lung fluid absorption, when present, was always propranolol and amiloride sensitive, suggesting that ␤-adrenoceptor stimulation and amiloridesensitive sodium channels were critical for fluid absorption. Epithelial sodium channel and Na-K-ATPase subunit expressions were both increased by IL-1␤, but not further by oxytocin. Our results indicate that IL-1␤ release into the maternal blood circulation positively affects lung maturation due to the IL-1␤-induced release of cortisol and thus prepares the lungs for the epinephrine surge associated with labor.␤-adrenoceptors; cortisol; epinephrine; prenatal lung development; sodium transport CYTOKINES, SUCH AS INTERLEUKIN-1 (IL-1), can be important during pregnancy, because IL-1 has been detected in the placenta and amniotic fluid (12,44). In this regard, interleukins have been proposed as a signal for parturition onset, as cytokines can stimulate prostaglandin biosynthesis (41). During normal pregnancies, IL-1 is present in the amniotic fluid in low concentrations, but during preterm labor much higher amniotic fluid IL-1 concentrations are present (44). Intrauterine infection/inflammation may further elevate cytokine levels, the highest activity being attributable to IL-1␤ (44). Many prematurely born infants suffer from fetal infection and/or respiratory distress syndrome (RDS), both of which are important reasons for mortality of premature babies. Recent human data suggest that ion transport abnormalities across lung epithelial cells, i.e., an incomplete transition of lung fluid secretion to lung fluid absorption, can contribute to RDS development (1). Factors accelerating ion transport across alveolar cells may thus have benefits for the resolution of RDS. Recent experimental data have suggested that proinflammatory cytokines could also promote lung maturation (9,14,26,47). IL-1␣ increased mRNA surfactant protein expression and improved lung compliance in fetal rabbits (9). IL-1␣ also improved postnatal lung function with increased surfactant pool size without eliciting systemic inflammatory responses in lambs (14, 47). We recently reported that IL-...

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“…Given the role of PDE4 in hormonal pathways (Mehats et al, 2002), one may speculate that at birth, hormonal regulations of postnatal lung physiology begin to be tightly regulated by selective PDE4s. Notably, clearance of fetal lung fluid is initiated secondary to beta-adrenergic-stimulated Na þ transport near term or at birth (Finley et al, 1998). Because PDE4D5 and PDE4D8 have been recently implicated in regulation of beta2-and beta1-adrenergic Fig.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of cyclic nucleotide phosphodiesterases 4 in developing rat lung

López

Jarreau

Zana

et al. 2010

Developmental Dynamics

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During the perinatal period, lungs undergo changes to adapt to air breathing. The genes involved in these changes are developmentally regulated by various signaling pathways, including the cyclic nucleotide cAMP. As PDE4s are critical enzymes for regulation of cAMP levels, the objective of this study was to investigate PDE4's ontogeny in developing rat lung during the perinatal period. Pulmonary PDE4 activity, PDE4A-D, PDE4B, and PDE4D variant expression levels, PDE4B and PDE4D protein levels, and PDE4D localization in distal lung were determined. PDE4 activity increased towards term, dropped at birth, and increased thereafter to reach a plateau at the end of the second week of life. PDE4B2 and PDE4D long forms demonstrated a pattern of expression that increased markedly at birth. After birth, PDE4D was expressed in alveolar epithelial and mesenchymal cells. The study, therefore, evidenced striking variations in expression patterns among the PDE4 family that differed from changes in global PDE4 activity. Developmental Dynamics 239:2470-2478,

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Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs.

Cited by 89 publications

References 49 publications

Invited Review: Clearance of lung liquid during the perinatal period

Invited Review: Clearance of lung liquid during the perinatal period

Oxytocin-induced labor augments IL-1β-stimulated lung fluid absorption in fetal guinea pig lungs

Differential expression of cyclic nucleotide phosphodiesterases 4 in developing rat lung

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