Alveolar echinococcosis localized in the liver, lung and brain

Kayacan, Seyit Mehmet; Vatansever, Sezai; Temiz, Süleyman; Uslu, Bora; Kayacan, Dilek; Akkaya, Vakur; Erk, Osman; Saka, Bülent; Karadağ, Aytaç; Türkmen, Kültiğin; Yakar, Fatih; Güler, Kerim

doi:10.1097/00029330-200801010-00018

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…AE is a rare but highly malignant form of echinococcosis, and it is caused by cyclophyllid tapeworm E. multilocularis . AE is generally presented in liver initially, and the majority of E. multilocularis infections is confined to the liver but may later spread to other organs, [ 14 ] mainly via blood circulation or lymphatic system. [ 13 , 14 ] In an analysis of 117 AE patients from eastern France, pulmonary metastasis occurred in about 20% of the patients whereas cerebral metastasis in only 1% and the simultaneous lung and brain metastases occurred in 1.1% of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…AE is generally presented in liver initially, and the majority of E. multilocularis infections is confined to the liver but may later spread to other organs, [ 14 ] mainly via blood circulation or lymphatic system. [ 13 , 14 ] In an analysis of 117 AE patients from eastern France, pulmonary metastasis occurred in about 20% of the patients whereas cerebral metastasis in only 1% and the simultaneous lung and brain metastases occurred in 1.1% of the patients. [ 15 ] Among 159 AE patients from western China, 35 (22%) patients had extrahepatic metastasis; among them, 8 (5%) patients developed multiorgan AE and 2 (1.25%) patients had spine metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients

Siyiti²,

Song³

et al. 2017

Medicine

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Rationale:Alveolar echinococcosis (AE) is a rare but highly malignant form of echinococcosis caused by Echinococcus multilocularis. There have been very few reports on multiple-organ AE, especially AE in bones. Here we report 3 rare cases of disseminated multiple-organ AE from western China and its neighboring areas.Patient concerns:Patient 1 had back and left hip pain, headache, and weakness in left lower limb, often with minor epilepsy and fluctuation of blood pressure. Lower limbs Babinski sign was positive and muscular tension was above normal range. The second patient had pain in lower limbs and chest discomfort without fever, cough, sputum, chest tightness, or hemoptysis. Patient 3 had masses and pain in the back side of his right shoulder.Diagnoses:The patients had been treated for AE multiple times and were positive for serum hydatid antigens. They were diagnosed as multiorgan AE involving liver, spinal cord, and many other organs.Interventions:The patients had undergone surgeries to decompress the spinal cord, remove lesions from tissues as required, and were put on albendazole for at least 2 years.Outcomes:The patients responded well and AE recurrence has not occurred.Lessons:All 3 cases experienced multiple recurrences of AE due to missed diagnosis, misdiagnosis, or inappropriate treatment, which resulted in metastatic multiorgan AE. These cases demonstrated the need for more policy attention to battle AE endemic in western China.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients

Siyiti²,

Song³

et al. 2017

Medicine

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“…With regard to human cases, an increased number of AE cases have been reported recently, who received immunosuppressive treatment for organ transplantation, malignant- and chronic inflammatory diseases (Gruener et al 2008; Kayacan et al 2008; Gaultier et al 2009; Geyer et al 2011; Kern et al . 2011; Weiner et al 2011 and Dentan et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Successful intestinal Echinococcus multilocularis oncosphere invasion and subsequent hepatic metacestode establishment in resistant RccHan™:WIST rats after pharmacological immunosuppression

et al. 2016

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Susceptibility/resistance to larval Echinococcus multilocularis infection varies greatly depending on host species and strains. Whereas several mice strains and non-human primates are highly susceptible to alveolar echinococcosis, rats and most of humans are considered as more resistant. In this study, we aimed to elucidate factors responsible for host resistance in rats (Experiments A-D). (A) The parasite establishment was not observed in immunocompetent Wistar rats orally inoculated with sodium hypochlorite resistant eggs with/without pig bile, or activated/non-activated oncospheres (NAO). Peritoneal inoculation with NAO or metacestode tissue allowed the parasite establishment in rats. (B) T-cell-deficient athymic nude rats showed complete resistance against the metacestode establishment after oral inoculation with parasite eggs. This finding suggests that T-cell-independent parasite clearance occurred in the animals during early phase of the parasite invasion. Finally, Wistar rats that received pharmacological immunosuppression using either dexamethasone (DMS) alone or methotrexate (MTX) i.p. alone or a combination of these compounds were orally inoculated with the parasite's eggs. As a result (D), successful establishment of metacestode with protoscoleces was observed in all 3 rats treated with DMS (s.c.) alone or in all 6 rats treated with DMS (s.c.) plus MTX but not in 8 rats with MTX alone, suggesting that factors affected by DMS treatment are responsible to regulate the parasite invasion and establishment.

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“…Fast progression of the lesions in a patient with AIDS (Sailer et al, 1997) and conversely the protective effect of efficacious anti-HIV treatment in another patient (Zingg et al, 2004) have confirmed the role of immune suppression in patients with AE. Since the beginning of the 21st century, a number of AE cases have been reported in patients who received other kinds of organ transplantation and/or were treated with imunosuppresive drugs for malignant or chronic inflammatory diseases (Dentan et al, 2012;Gaultier et al, 2009;Geyer et al, 2011;Gruener et al, 2008;Kayacan et al, 2008; The increase in the occurrence of AE in such patients was evidenced in a systematic study using the data from the population-based AE French registry database (Chauchet et al, 2014): 50 patients were found with such immunosuppressionassociated (IS) conditions before or at AE diagnosis, among 509 AE cases diagnosed from 1982 to 2012. There was a significant increase in AE incidence in such patients, and significantly higher increase than in non-IS cases between the last 2 decades.…”

Section: Immunosuppressionmentioning

confidence: 99%

Echinococcus spp.

Vuitton¹,

Zhang²,

Giraudoux³

2019

Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Wate

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The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The ideas and opinions expressed in this publication are those of the authors; they are not necessarily those of UNESCO and do not commit the Organization.

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Alveolar echinococcosis localized in the liver, lung and brain

Cited by 15 publications

References 7 publications

Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients

Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients

Successful intestinal Echinococcus multilocularis oncosphere invasion and subsequent hepatic metacestode establishment in resistant RccHan™:WIST rats after pharmacological immunosuppression

Echinococcus spp.

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