Alveolar Cell Carcinoma

Marzano, Mino; Deschler, Thomas; Mintzer, Richard A.

doi:10.1378/chest.86.1.123

Cited by 10 publications

(1 citation statement)

References 13 publications

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“…BAC constitutes 1-5% of lung carcinomas in most series 17 and may present as lobar consolidation radiographically, as slow growing solitary nodules or as multiple, rapidly developing satellite nodules, with resultant widespread bilateral disease. [18][19][20] The average age at presentation is in the sixth decade but younger patients, as in this case, have been reported, even in the second decade. 21 22 The key histological picture of BAC is the growth of cuboidal and columnar tumour cells along intact alveolar walls either in a single layer or forming papillae.…”

Section: Metastatic Tumours Of Pituitary Glandmentioning

confidence: 61%

Bronchioloalveolar carcinoma with metastasis to the pituitary gland: a case report.

Lau¹,

Tan²,

Chiang³

et al. 1998

J Clin Pathol

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An unusual case of metastatic bronchioloalveolar carcinoma of the lung presented as a pituitary tumour in a young adult Chinese female, who subsequently died after having undergone trans-spheoidal resection. Metastatic cancers of the pituitary are uncommon even in necropsy series and rarely give rise to clinical symptoms. This case draws attention to the fact that, although uncommon, pituitary metastases have been noted with increasing frequency and their distinction from primary pituitary tumours is often diYcult. A metastatic pituitary tumour may be the initial presentation of an unknown primary malignancy, wherein the metastatic deposits may also be limited to the pituitary gland. Clinicians and pathologists alike should consider a metastatic lesion in the diVerential diagnosis of a non-functioning pituitary tumour. (J Clin Pathol 1998;51:931-934) Keywords: bronchioloalveolar carcinoma; pituitary metastasis; perioperative death Case history A 36 year old Chinese woman, who presented with recurrent headaches and diplopia, was initially diagnosed as having migraine and was treated for this. Her past history included a left hemithyroidectomy for nodular goitre with lymphocytic thyroiditis approximately three years before. Computed tomography of the brain, which was done during her current hospital admission, was apparently normal and she was discharged about a week later.However, she was readmitted barely 10 days later, having had two episodes of what was described as near collapse. After a few days, she showed clinical signs of bilateral abducens nerve palsy and early right papilloedema. Magnetic resonance imaging of the brain suggested the presence of a tumour of the pituitary gland, with suprasellar extension. She then underwent trans-sphenoidal exploration of the pituitary fossa, and an unusually vascular tumour was resected. Subsequent histological examination showed features consistent with a metastatic carcinoma (see below). Interestingly, a preoperative chest radiograph had shown a left hilar mass lesion, but this was thought to be unrelated to the pituitary tumour at that time. Her preoperative plasma electrolyte profile was noted to have been normal. Postoperatively, the patient was initially in a stable condition. There was no evidence of any leakage of cerebrospinal fluid or of meningitis. Perioperative antibiotic prophylaxis and steroid cover were given and early electrolytic disturbances caused by transient diabetes insipidus were corrected. Unexpectedly, on the second postoperative day, she suddenly collapsed while dressing herself. Computed tomography of the brain showed evidence of cerebral oedema, without haemorrhage. Despite intensive medical support, which included broad spectrum antibiotics, mannitol infusion, and continued steroid cover, she subsequently died and a coroner's necropsy was carried out. Necropsy findingsDuring necropsy examination, both lungs were found to be markedly consolidated, oedematous, and congested. The lingula of the left lung contained a yellowish subpleu...

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Section: Metastatic Tumours Of Pituitary Glandmentioning

confidence: 61%