Alveolar bone regeneration using absorbable poly(L-lactide-co-ɛ-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor

Kinoshita, Yukihiko; Matsuo, Masato; Todoki, Kazuo; Ozono, Satoru; Fukuoka, Shin-Ichi; Tsuzuki, Hideko; Nakamura, Minoru; Tomihata, Kenji; Shimamoto, Tadashi; Ikada, Yoshihito

doi:10.1016/j.ijom.2007.11.010

Cited by 34 publications

(27 citation statements)

References 16 publications

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“…Although they do not require a second surgery, they present limitations regarding their ability to provide space for bone formation, early/late absorption, mechanical strength, and inflammatory reaction during biodegradation [16–18, 29]. To overcome the limitations of biodegradable synthetic polymers while maintaining their advantages, polymer-calcium phosphate composites have been investigated [30–32]. Inorganic materials, such as calcium phosphates, are expected to provide rigidity to the soft polymer, the osteoconductivity, the PH buffering effect in the surrounding tissue, and the X-ray impermeability making it possible to monitor the GBR membrane after implantation.…”

Section: Scaffolds For Acellular Bone Tissue Engineeringmentioning

confidence: 99%

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Kinoshita

Maeda

2013

The Scientific World Journal

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Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies.

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Section: Scaffolds For Acellular Bone Tissue Engineeringmentioning

confidence: 99%

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Kinoshita

Maeda

2013

The Scientific World Journal

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“…These include low space-maintaining ability due to weak mechanical properties, and rapid degradation and absorption [11,12]. Recent, studies have focused on improving the space-maintaining abilities and mechanical properties of resorbable membranes using different fabrication methods and synthetic biodegradable materials [13,14,15]. Of the various fabrication methods used, in combination with synthetic biodegradable materials, three-dimensional (3D) printing enables resorbable membranes to be made without toxic solvents and allows membrane thicknesses, pore sizes, and shapes to be easily adjusted to create favorable environments for cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Shim

Won²,

Park

et al. 2017

IJMS

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This study was conducted to compare 3D-printed polycaprolactone (PCL) and polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) membranes with a conventional commercial collagen membrane in terms of their abilities to facilitate guided bone regeneration (GBR). Fabricated membranes were tested for dry and wet mechanical properties. Fibroblasts and preosteoblasts were seeded into the membranes and rates and patterns of proliferation were analyzed using a kit-8 assay and by scanning electron microscopy. Osteogenic differentiation was verified by alizarin red S and alkaline phosphatase (ALP) staining. An in vivo experiment was performed using an alveolar bone defect beagle model, in which defects in three dogs were covered with different membranes. CT and histological analyses at eight weeks after surgery revealed that 3D-printed PCL/β-TCP membranes were more effective than 3D-printed PCL, and substantially better than conventional collagen membranes in terms of biocompatibility and bone regeneration and, thus, at facilitating GBR.

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“…These effects may be due to the presentation of the membrane used, as Reis et al (2011), with a complex topography membrane were able to demonstrate, by micro tomography, bone regeneration in similar defects. Other membranes have also demonstrated a positive effect (Kinoshita et al, 2008;Iwata et al, 2009). Still analyzing the values for BV/TV (Tab.…”

Section: Resultsmentioning

confidence: 97%

Treatment of periodontal disease with guided tissue regeneration technique using a hydroxyapatite and polycaprolactone membrane

Martins

Valente

Reis

et al. 2016

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to evaluate the use of a malleable membrane composed of hydroxyapatite (60%) and polycaprolactone (40%) as treatment of periodontal disease experimentally induced in dogs. A bone defect of standardized dimensions was created between the roots of the third and fourth premolar of 12 dogs for periodontal disease induction. Six dogs had the defect covered by the membrane and six dogs received only standard treatment for periodontal disease, also applied to dogs in the treated group. The animals were clinically monitored during the experiment. Radiographs were taken after surgery and at 60 days after treatment initiation. Clinical attachment level was also assessed in those moments. On the 60th day, dental sample of all animals, containing tooth, defect and periodontal tissues, were harvested, fixed in formalin and analyzed by microtomography and histology. During the experimental period, the animals showed no pain and purulent discharge, however, there was dehiscence in 50% of animals and membrane exposure in five out of six animals in the treated group. Clinical attachment level showed no difference between groups. Radiographs showed radiopacity equal to the alveolar bone in both groups. The microtomography revealed that the control group had higher bone volume in the defect compared to the treated group; however, the furcation was not filled by new alveolar bone in any animal. Histological analysis revealed that junctional epithelium invasion was lighter in the control group. New bone was only observed in the apical edge of the defect in both groups. Although the composite is biocompatible and able to keep the space of the defect, it did not promote periodontal tissue regeneration within 60 days of observation.

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Alveolar bone regeneration using absorbable poly(L-lactide-co-ɛ-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor

Cited by 34 publications

References 16 publications

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Treatment of periodontal disease with guided tissue regeneration technique using a hydroxyapatite and polycaprolactone membrane

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