Alveolar-arterial oxygen gradient in acute chest syndrome of sickle cell disease

Acute Chest Syndrome in Sickle Cell Disease in Saudi Arab Children in the Eastern Province

“…A simple scoring system was used to assess the degree of clinical severity: score "0" was made when there was no respiratory distress, which indicated mild disease; score "1" was made when there was tachypnea (age adjusted), which indicated moderate severity; and score "2" was made when there were tachypnea and retraction, which indicated severe disease. 16 Patients with severe disease were admitted in pediatric intensive care unit. All patients were treated with intravenous fluid.…”

Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease

“…A respiratory clinical severity score (RCSS) was used wherein normal respirations = 0, tachypnea = 1, and tachypnea and retractions=2 [11].…”

Measurement of hemoglobin saturation by oxygen in children and adolescents with sickle cell disease

“…5,10,11 Fractional oxyhemoglobin (FO 2 Hb) refers to the amount of oxyhemoglobin as a fraction of total hemoglobin (cO 2 Hb/ctHb). 10 When expressed as a percentage, FO 2 Hb is often referred to as fractional saturation. The difference between SO 2 and FO 2 Hb is due to the presence of dyshemoglobins such as carboxyhemoglobin (COHb) and methemoglobin (MetHb), which cannot bind oxygen.…”

“…1 The detection of oxyhemoglobin desaturation with or without accompanying hypoxemia is essential to the initiation of therapy that may prevent or alleviate complications of SCD. 2,3 Pulse oximetry is a noninvasive method of measuring oxyhemoglobin saturation. The validity of pulse oximetry in SCD has been questioned, [4][5][6] with concerns raised about its ability to predict arterial oxygen tension.…”