Alveolar-arterial gas tension relationships in acute anterior poliomyelitis

Saxton, George A.; Rayson, Glenn E.; Moody, Edward B.; McGrath, Thomas D.; Kaminski, Jamie

doi:10.1016/0002-9343(61)90175-9

“…For instance, in the emphysematous patients studied by Donald, Renzetti, Riley, and Cournand, physiologic dead space to tidal volume ratios ranged from 0.29 to 0.59, and in the patients investigated with interstitial fibrosis or pneumonitis physiologic dead space to tidal volume ratios ranged from 0.21 to 0.67 (21). Similar values have been reported for patients with poliomyelitis ventilated in a tank respirator (2).…”

Section: Discussionsupporting

confidence: 66%

“…The frequent occurrence of an increased physiologic dead space (2,3) and of increased physiologic shunting (3) in patients undergoing prolonged artificial ventilation has previously been described. These changes in ventilation-perfusion ratios mean that very large tidal volumes and high percentages of inspired oxygen are often required to maintain life during prolonged intermittent positive pressure ventilation.…”

mentioning

confidence: 99%

The response of patients with respiratory failure and cardiopulmonary disease to different levels of constant volume ventilation.

Hedley-Whyte¹,

Pontoppidan²,

Morris³

1966

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The purpose of this study was to determine the effect of increasing the tidal volume on pulmonary ventilation-perfusion relations in patients with respiratory failure caused by cardiopulmonary disease.The frequent occurrence of an increased physiologic dead space (2, 3) and of increased physiologic shunting (3) in patients undergoing prolonged artificial ventilation has previously been described. These changes in ventilation-perfusion ratios mean that very large tidal volumes and high percentages of inspired oxygen are often required to maintain life during prolonged intermittent positive pressure ventilation. The aim of our study was to measure the consequences of changing the tidal volume, but not the respiratory frequency, of patients with respiratory failure secondary to either acute intrapulmonary infection or chronic pulmonary emphysema. MethodsSelection of patients. At the time of the study none of the twelve patients had a total vital capacity above 400 ml, and hence all were completely dependent on intermittent positive pressure ventilation. Eight of the patients studied were selected because they had been free of symptomatic pulmonary disease on admission to the hospital, but had later developed nonemphysematous cardiopulmonary disease and acute intrapulmonary infection that caused respiratory failure. Polyethylene catheters were placed percutaneously in either a radial or femoral artery and in the superior vena cava. These catheters were used for blood sampling and continuous pressure recording via a Sanborn 350 system. Continuous intratracheal pressure and the electrocardio- 1 The apparatus dead space, average volume 28 ml, extended from the tip of the tracheostomy tube lying in the trachea to the junction of the inspiratory and expiratory tubes of the ventilator, a distance of 25 cm; the internal diameter of the tubing that comprised the apparatus dead space was 1.2 cm. 1543

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“…The physiologic shunt3 Qs/Q was calculated by the standard physiologic shunt equation (11): Qs/Q = Cco2 -Gao2 E Cco2 -Cv02' [2] where Cco2 is the oxygen content that the patient's arterial blood would have had if equilibrated with mean alveolar gas, CaO2 is arterial oxygen content, and Cvo2 is the oxygen content of mixed venous blood. (In this study superior vena caval blood oxygen content substituted for pulmonary arterial blood oxygen content.…”

Section: Methodsmentioning

confidence: 99%

The Response of Patients With Respiratory Failure and Cardiopulmonary Disease to Different Levels of Constant Volume Ventilation

Hedley-Whyte

¹

,

Pontoppidan

²

,

Morris

³

1967

Survey of Anesthesiology

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The purpose of this study was to determine the effect of increasing the tidal volume on pulmonary ventilation-perfusion relations in patients with respiratory failure caused by cardiopulmonary disease.The frequent occurrence of an increased physiologic dead space (2, 3) and of increased physiologic shunting (3) in patients undergoing prolonged artificial ventilation has previously been described. These changes in ventilation-perfusion ratios mean that very large tidal volumes and high percentages of inspired oxygen are often required to maintain life during prolonged intermittent positive pressure ventilation. The aim of our study was to measure the consequences of changing the tidal volume, but not the respiratory frequency, of patients with respiratory failure secondary to either acute intrapulmonary infection or chronic pulmonary emphysema. MethodsSelection of patients. At the time of the study none of the twelve patients had a total vital capacity above 400 ml, and hence all were completely dependent on intermittent positive pressure ventilation. Eight of the patients studied were selected because they had been free of symptomatic pulmonary disease on admission to the hospital, but had later developed nonemphysematous cardiopulmonary disease and acute intrapulmonary infection that caused respiratory failure. Polyethylene catheters were placed percutaneously in either a radial or femoral artery and in the superior vena cava. These catheters were used for blood sampling and continuous pressure recording via a Sanborn 350 system. Continuous intratracheal pressure and the electrocardio- 1 The apparatus dead space, average volume 28 ml, extended from the tip of the tracheostomy tube lying in the trachea to the junction of the inspiratory and expiratory tubes of the ventilator, a distance of 25 cm; the internal diameter of the tubing that comprised the apparatus dead space was 1.2 cm. 1543

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Zur quantitativen Feststellung der Lungenfunktion für klinische und arbeitsmedizinische Fragestellungen

Fruhmann

¹

,

Sturm

²

1965

Z. Gesamte Exp. Med.

1

0

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Alveolar-arterial gas tension relationships in acute anterior poliomyelitis

Cited by 5 publications

References 13 publications

The response of patients with respiratory failure and cardiopulmonary disease to different levels of constant volume ventilation.

The response of patients with respiratory failure and cardiopulmonary disease to different levels of constant volume ventilation.

The Response of Patients With Respiratory Failure and Cardiopulmonary Disease to Different Levels of Constant Volume Ventilation

Zur quantitativen Feststellung der Lungenfunktion für klinische und arbeitsmedizinische Fragestellungen

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