Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour

Halldorsson, Ari; Kaye, Kim Sutker

doi:10.1136/jcp.2004.020800

Cited by 26 publications

(22 citation statements)

References 9 publications

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“…Additionally, epithelia are positive for type II pneumocyte markers, indicating that the epithelial layer is derived from type II pneumocytes (16). In cases where the epithelial layer is flattened in shape and resembles the endothelium, the absence of immunostaining for CD31 or CD34 vascular markers may help to distinguish alveolar adenoma from other pulmonary lesions (17,18).…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of lung alveolar adenoma with cerebral arteriovenous malformations: A case report and literature review

Tang

Shen

2015

Oncology Letters

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Abstract. Alveolar adenoma is an extremely rare benign tumor of the lung derived from type II pneumocytes. To date, only a limited number of alveolar adenoma cases have been reported in the literature. These tumors are usually discovered incidentally on radiographic images. However, other tumor types must be excluded when the characteristics of alveolar adenoma are not typical on the radiographic images. Therefore, diagnosis of alveolar adenomas is based on the combination of gross structural analysis and immunohistochemistry. The present study described a case of alveolar adenoma in a 47-year-old female patient. A chest X-ray revealed a pulmonary lesion in the right lower lobe and, subsequently, the patient underwent a right lower lobectomy. Pathological examination of the surgically resected tissue confirmed the initial diagnosis of alveolar adenoma. In addition, intracranial vascular malformations were detected on a computed tomography scan, but the patient did not experience any notable symptoms. Considering the benign nature of the malformations, as determined by digital subtraction angiography, the patient selected to undergo follow-up with observation only. The postoperative course was uneventful and no recurrence of pulmonary lesions was noted after >4 years, while the condition of the intracranial lesion was stable. In conclusion, the current study described a unique case of adenoma alveolar coexisting with intracranial vascular malformations. A literature review of previously-reported alveolar adenoma cases was also conducted.

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Section: Discussionmentioning

confidence: 99%

“…Previous immunohistochemical studies have demonstrated that alveolar adenoma epithelia are positive for markers including pan-CK, epithelial membrane antigen and TTF-1 (16). Additionally, epithelia are positive for type II pneumocyte markers, indicating that the epithelial layer is derived from type II pneumocytes (16).…”

Section: Discussionmentioning

confidence: 99%

Coexistence of lung alveolar adenoma with cerebral arteriovenous malformations: A case report and literature review

Tang

Shen

2015

Oncology Letters

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“…Alveolar adenoma (AA) is a rare pulmonary tumour of uncertain histogenesis. Only 25 cases of AA have been reported in the English medical literature (Table 1) (1–10). Yousem & Hochholzer initially described AA in 1986 (6).…”

Section: The Cases Reported In the English Language Literaturementioning

confidence: 99%

“…AA is a solitary, well‐demarcated peripheral pulmonary lesion composed of a network of spaces lined with simple cuboidal epithelium that contain stroma ranging from thin inconspicuous strands of connective tissue to broad accumulations of spindle cells accompanied by a myxoid matrix (3). The epithelial component consists of type‐II pneumocytes (3, 5, 6, 8). Most authors agree that these tumours are histologically benign, and recurrence has never been reported after resection (3, 6, 9).…”

Section: The Cases Reported In the English Language Literaturementioning

confidence: 99%

Alveolar adenoma of the lung

Sak

Köseoğlu

Demırağ

et al. 2007

APMIS

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Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as a coin lesion on chest radiography. Only 25 cases have been reported in the English medical literature. Alveolar adenoma has a characteristic multicystic histology and often resembles the normal lung parenchyma. Ultrastructural studies indicate that the epithelial cells lining the cysts are type-II pneumocytes. Immunohistochemical analysis may aid in the characterization of alveolar adenoma and discriminate this condition from other types of benign lesions of the lung. An indolent clinical progression and absence of recurrence and metastasis after complete resection are the most important characteristics indicative of the benign nature of alveolar adenoma. Few studies have been conducted at the molecular level, such as by flow cytometry, with the objective of characterizing the biological nature of alveolar adenoma. Differential diagnoses include sclerosing hemangioma, papillary adenoma, lymphangioma, atypical adenomatous hyperplasia and bronchioloalveolar carcinoma. In this article we describe the immunohistochemical and flow cytometric features of this neoplasm in two male patients. Both the tumours showed a diploid DNA pattern with a low proliferation index. p53 test was found to be negative, and post-operative follow-up examinations at 22 and 32 months proved uneventful.

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“…Burke publizierte 1999 [1] die größte Serie mit siebzehn Fällen, die Fälle von Yousem und Hochholzer mit eingeschlossen. Er postulierte in seiner Arbeit präzise pathologische Kriterien, nach welchen bis 2005 weltweit nur 25 Fälle beschrieben worden sind [3]. Das Alveolarzelladenom bleibt in der Regel symptomlos und wird -wenn überhaupt -inzidentiell als solitäre isolierte gut begrenzte Läsion im Thoraxbild entdeckt.…”

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Das alveoläre Adenom als Differenzialdiagnose zum Bronchialkarzinom: Fallvorstellung und Literaturreview

et al. 2009

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This report describes the case of a 58-year-old man presenting with haemoptysis. Chest X-ray and CT scans showed a solitary pulmonary mass in the right lower lobe without radiographic signs of malignancy. Definitive histology following thoracoscopic wedge resection showed the distinctive findings of an alveolar adenoma, a very rare benign tumour of the lung of unknown histogenesis. Its existence was first described in 1986 with less than 30 cases published to this day. Alveolar adenoma usually presents as a peripheral solitary lesion in asymptomatic, older patients. Its histological features, the benign proliferation of alveolar epithelium and septal mesenchyme, allow for its distinction from other benign lesions of the lung. Complete excision is considered curative on the basis of current knowledge.

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Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour

Cited by 26 publications

References 9 publications

Coexistence of lung alveolar adenoma with cerebral arteriovenous malformations: A case report and literature review

Coexistence of lung alveolar adenoma with cerebral arteriovenous malformations: A case report and literature review

Alveolar adenoma of the lung

Das alveoläre Adenom als Differenzialdiagnose zum Bronchialkarzinom: Fallvorstellung und Literaturreview

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