Abstract:Background
While next generation sequencing (NGS) has enabled massive parallel analysis of different human genomes, strategies are required to maximize its signal‐to‐noise ratio in the data generated and its accessibility for clinical settings. While whole exome sequence (WES) can capture subsets of whole genome sequences (WGS), thereby reducing cost and time of analysis, it is inapplicable to non‐protein coding sequences. Pre‐sequencing capture methods are therefore needed to optimize the collection of genome… Show more
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