Aluminum Lactate Treatment Alters the Lung Biological Activity of Quartz

Bégin, Raymond; Massé, S.; Rola‐Pleszczynski, Marek; Martel, Marc; Desmarais, Y.; Geoffroy, M.; LeBouffant, L.; Daniel, H.; Martín, Juan Luis Afonso

doi:10.3109/01902148609058289

Cited by 43 publications

(26 citation statements)

References 12 publications

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“…Polyvinylpyridine- N -oxide (PVPNO) and aluminium salts have already been tested as non-covalent surface modifications to treat or prevent silicosis, however, with limited success (Weller, 1975; Zhao et al , 1983; Prügger et al , 1984; Bégin et al , 1986; Goldstein and Rendall, 1987; Dubois et al , 1988; Dufresne et al , 1994; Bégin et al , 1995). PVPNO forms strong hydrogen bonds via NO − groups, thus masking negatively charged SiO − groups (reviewed by Castranova, 1995), whereas aluminium lactate (AL) can block surface charges and radical formation via the aluminium cation and related ionic forces (Bégin et al , 1986; Brown et al , 1989; Duffin et al , 2001; Albrecht et al , 2004, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…PVPNO forms strong hydrogen bonds via NO − groups, thus masking negatively charged SiO − groups (reviewed by Castranova, 1995), whereas aluminium lactate (AL) can block surface charges and radical formation via the aluminium cation and related ionic forces (Bégin et al , 1986; Brown et al , 1989; Duffin et al , 2001; Albrecht et al , 2004, 2007). AL seems to be less effective in vivo than PVPNO, perhaps because of different modes of action and differential modification of cell type-specific uptake and elimination of treated quartz by alveolar macrophages (AM) (Höhr et al , 2002; Albrecht et al , 2007, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Organosilane-Based Coating of Quartz Species from the Traditional Ceramics Industry: Evidence of Hazard Reduction Using In Vitro and In Vivo Tests

Ziemann

Escrig

Bonvicini

et al. 2017

Annals of Work Exposures and Health

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The exposure to respirable crystalline silica (RCS), e.g. quartz, in industrial settings can induce silicosis and may cause tumours in chronic periods. Consequently, RCS in the form of quartz and cristobalite has been classified as human lung carcinogen category 1 by the International Agency for Research on Cancer in 1997, acknowledging differences in hazardous potential depending on source as well as chemical, thermal, and mechanical history. The physico-chemical determinants of quartz toxicity are well understood and are linked to density and abundance of surface silanol groups/radicals. Hence, poly-2-vinylpyridine-N-oxide and aluminium lactate, which effectively block highly reactive silanol groups at the quartz surface, have formerly been introduced as therapeutic approaches in the occupational field. In the traditional ceramics industry, quartz-containing raw materials are indispensable for the manufacturing process, and workers are potentially at risk of developing quartz-related lung diseases. Therefore, in the present study, two organosilanes, i.e. Dynasylan® PTMO and Dynasylan® SIVO 160, were tested as preventive, covalent quartz-coating agents to render ceramics production safer without loss in product quality. Coating effectiveness and coating stability (up to 1 week) in artificial alveolar and lysosomal fluids were first analysed in vitro, using the industrially relevant quartz Q1 as RCS model, quartz DQ12 as a positive control, primary rat alveolar macrophages as cellular model system (75 µg cm−2; 4 h of incubation ± aluminium lactate to verify quartz-related effects), and lactate dehydrogenase release and DNA strand break induction (alkaline comet assay) as biological endpoints. In vitro results with coated quartz were confirmed in a 90-day intratracheal instillation study in rats with inflammatory parameters as most relevant readouts. The results of the present study indicate that in particular Dynasylan® SIVO 160 (0.2% w/w of quartz) was able to effectively and stably block toxicity of biologically active quartz species without interfering with technical process quality of certain ceramic products. In conclusion, covalent organosilane coatings of quartz might represent a promising strategy to increase workers’ safety in the traditional ceramics industry.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organosilane-Based Coating of Quartz Species from the Traditional Ceramics Industry: Evidence of Hazard Reduction Using In Vitro and In Vivo Tests

Ziemann

Escrig

Bonvicini

et al. 2017

Annals of Work Exposures and Health

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“…In addition, PVNO has also been described as a scavenger of free radicals and thus may inhibit production of reactive oxygen species (ROS) and induction of oxidative stress by quartz (Gulumian & van Wyk, 1987;Fubini, 1998a). Coating with aluminum lactate (AL) has also been reported to reduce cytotoxicity of quartz (Begin et al, 1986(Begin et al, , 1987Fubini, 1998a). Moreover, aluminum coatings have been shown to reduce oxidative stress, pulmonary inflammation and silicosis (Begin et al, 1993;Dufresne et al, 1994;Duffin et al, 2001;Albrecht et al, 2005).…”

mentioning

confidence: 97%

Surface-Dependent Quartz Uptake by Macrophages: Potential Role in Pulmonary Inflammation and Lung Clearance

Albrecht

Höhr

Haberzettl

et al. 2007

Inhalation Toxicology

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Inhalation of quartz particles is associated with a variety of adverse lung effects. Since particle surface is considered to be crucial for particle pathogenicity, we investigated the influence of quartz surface properties on lung burden, inflammation (bronchoalveolar lavage cells), and cytotoxicity (protein, lactate dehydrogenase, beta-glucuronidase) 90 days after a single intratracheal instillation of 2 mg DQ12 into rats. The role of particle surface characteristics was investigated by comparative investigation of native versus surface-modified quartz, using polyvinylpyridine N-oxide (PVNO) or aluminum lactate (AL) coating. Uptake and subcellular localization of quartz samples as well as tumor necrosis factor (TNF)-alpha release were determined using NR8383 rat alveolar macrophages. Surface modification of quartz particles resulted in marked in vivo and in vitro changes. Compared to native quartz, modified quartz samples showed lower lung burden at 90 days, as well as decreased inflammatory and cytotoxic responses. Coating with polyvinylpyridine N-oxide (PVNO) appeared to be more effective than aluminium lactate (AL). PVNO-coating of quartz also resulted in an enhanced particle uptake by macrophages up to 24 h, whereas AL coating caused a transient reduction of quartz uptake at 2 h. At 24 h differences with the native quartz were absent. Subcellular localization of quartz particles was not affected by surface modifications. However, surface modification resulted in a reduced release of TNF-alpha. In conclusion, surface properties of quartz particles appear to be crucial for rate and extent of in vitro particle uptake in macrophages. Our in vivo findings also indicate that quartz surface properties may affect clearance kinetics. Particle surface-specific interactions between quartz and macrophages may therefore play a major role in the pulmonary pathogenicity of quartz.

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“…This postulate has been repeatedly verified by various researchers [15][16][17][18][19][20][21][22][23] who managed to reduce its toxicity at lab scale, on treating quartz with different substances: polyvinylpyridine-N-oxide (PVPNO) [15], organosilanes [16][17], aluminium lactate [18][19][20][21][22] and strong Lewis acids, such as AlCl 3 or FeCl 3 [23].…”

Section: Introductionmentioning

confidence: 83%

Additives for reducing the toxicity of respirable crystalline silica. SILIFE project

et al. 2017

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Abstract. Prolonged inhalation of crystalline silica particles has long been known to cause lung inflammation and development of the granulomatous and a fibrogenic lung disease known as silicosis. The International Agency for Research on Cancer (IARC) has classified Respirable Crystalline Silica (RCS) in the form of quartz and cristobalite from occupational sources as carcinogenic for humans (category 1). In this regard, numerous studies suggest that the toxicity of quartz is conditioned by the surface chemistry of the quartz particles and by the density and abundance of silanol groups. Blocking these groups to avoid their interaction with cellular membranes would theoretically be possible in order to reduce or even to eliminate the toxic effect. In this regard, the main contribution of the presented research is the development of detoxifying processes based on coating technologies at industrial scale, since the previous studies reported on literature were carried out at lab scale. The results obtained in two European projects showed that the wet method to obtain quartz surface coatings (SILICOAT project) allows a good efficiency in inhibiting the silica toxicity, and the preliminary results obtained in an ongoing project (SILIFE) suggest that the developed dry method to coat quartz surface is also very promising. The development of both coating technologies (wet and a dry) should allow these coating technologies to be applied to a high variety of industrial activities in which quartz is processed. For this reason, a lot of end-users of quartz powders will be potentially benefited from a reduced risk associated to the exposure to RCS.

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Aluminum Lactate Treatment Alters the Lung Biological Activity of Quartz

Cited by 43 publications

References 12 publications

Organosilane-Based Coating of Quartz Species from the Traditional Ceramics Industry: Evidence of Hazard Reduction Using In Vitro and In Vivo Tests

Organosilane-Based Coating of Quartz Species from the Traditional Ceramics Industry: Evidence of Hazard Reduction Using In Vitro and In Vivo Tests

Surface-Dependent Quartz Uptake by Macrophages: Potential Role in Pulmonary Inflammation and Lung Clearance

Additives for reducing the toxicity of respirable crystalline silica. SILIFE project

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