Aluminum, environment and central nervous system disease

Perl, D. P.; Good, Paul F.

doi:10.1080/09593338809384649

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Apesar de a concentração de alumínio na água ser controlada por aspectos organolépticos, existe um considerável debate no círculo médico relatando o papel deste metal na incidência do mal de Alzheimer, que é uma doença cerebral degenerativa de etiologia desconhecida caracterizada pela presença de um grande número de estruturas neurofíbrilares e placas senis em certas regiões do cérebro (Perl, 1988). O alumínio é um composto neurotóxico que, a longo prazo, pode causar encefalopatia grave em pacientes que sofrem diálise renal, podendo levar à distúrbios neurológicos.…”

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Importância da análise de água para a saúde pública em duas regiões do Estado do Rio de Janeiro: enfoque para coliformes fecais, nitrato e alumínio

2001

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In developing countries, due to poor sanitation conditions and poor quality of drinking water, typical water-borne diseases and more recently diseases caused by drinking water with high concentrations of nitrates and certain metals like aluminum have increased the concern over the health effects of these compounds. Several articles have shown associations between nitrates and methemoglobinemia in children, and aluminum and Alzheimer disease in adults. This study identified water quality with several parameters in non-conformity with Brazilian drinking water standards (Ruling 36/90): more than 50% of all samples from both regions contained fecal coliforms; some 31% of water samples from wells in Duque de Caxias had excessive nitrate concentrations; 100% of all groundwater samples from both regions showed aluminum concentrations not conforming to the norm, with the same result for 100% of samples from the drinking water distribution system in São Gonçalo and 75% of same in Duque de Caxias. This lack of conformity poses several health risks for the local population.

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Importância da análise de água para a saúde pública em duas regiões do Estado do Rio de Janeiro: enfoque para coliformes fecais, nitrato e alumínio

2001

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“…18,19 Aluminum-protein complexes may cross the blood-brain barrier through transferrin, although the actual mode of uptake of aluminum has yet to be determined. 20,21 We have postulated that the high levels of ingested aluminum by this mother during pregnancy, with the increased aluminum exposure in this vulnerable period of brain development, resulted in neurologic impairment in this infant. In retrospect, anemia and poor bone mineralization of the acetabula observed at 4 months of age may have been due to aluminum toxicity.…”

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confidence: 99%