Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response

Sjogren, Caroline A.; Bolaris, Stephen C; Larsen, Paul B.

doi:10.1105/tpc.15.00172

Cited by 96 publications

(123 citation statements)

References 31 publications

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“…During a plant's normal growth in the soil, a growing root tip might encounter a persistent source of DNA damage, such as from the presence of a toxic heavy metal (Hu et al, 2016;Sjogren et al, 2015). In this scenario, the preferential growth of lateral roots (rather than a futile cycle of primary root DDR-induced PCD and regeneration) could successfully redirect root growth away from the chronic DNA-damaging agent.…”

Section: Sog1 Is Required For Cell Cycle Arrest Immediately After Irmentioning

confidence: 99%

SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration

et al. 2017

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Section: Sog1 Is Required For Cell Cycle Arrest Immediately After Irmentioning

confidence: 99%

SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration

et al. 2017

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“…; Sjogren et al . ). SOG1 regulates hundreds of genes involved in cell cycle arrest, stem cell death, early onset of endoreplication and DNA repair (Yoshiyama et al .…”

Section: Resultsmentioning

confidence: 97%

“…Recently, it has been shown that high aluminum stress specifically activates the ATR–SOG1 pathway and inhibits root growth (Sjogren et al . ); therefore, ATM and ATR may respond differentially to external cues and control primary and LR growth.…”

Section: Discussionmentioning

confidence: 99%

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DNA damage inhibits lateral root formation by up‐regulating cytokinin biosynthesis genes in Arabidopsis thaliana

et al. 2016

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Lateral roots (LRs) are an important organ for water and nutrient uptake from soil. Thus, control of LR formation is crucial in the adaptation of plant growth to environmental conditions. However, the underlying mechanism controlling LR formation in response to external factors has remained largely unknown. Here, we found that LR formation was inhibited by DNA damage. Treatment with zeocin, which causes DNA double-strand breaks, up-regulated several DNA repair genes in the LR primordium (LRP) through the signaling pathway mediated by the transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1). Cell division was severely inhibited in the LRP of zeocin-treated sog1-1 mutant, which in turn inhibited LR formation. This result suggests that SOG1-mediated maintenance of genome integrity is crucial for proper cell division during LRP development. Furthermore, zeocin induced several cytokinin biosynthesis genes in a SOG1-dependent manner, thereby activating cytokinin signaling in the LRP. LR formation was less inhibited by zeocin in mutants defective in cytokinin biosynthesis or signaling, suggesting that elevated cytokinin signaling is crucial for the inhibition of LR formation in response to DNA damage. We conclude that SOG1 regulates DNA repair and cytokinin signaling separately and plays a key role in controlling LR formation under genotoxic stress.

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“…However, the exact mechanism by which Al inhibits this wall loosening is not clear (for example, it seems that Al interferes either directly or indirectly with factors that influence the organization of the cytoskeleton (Sivaguru et al ., ; Sivaguru et al ., )), and other toxic effects of Al (such as on cell division and cell cycling, for example see Doncheva et al ., (); Sjogren et al . (), and Nezames et al . ()) also require consideration.…”

Section: Introductionmentioning

confidence: 88%

Role of phytohormones in aluminium rhizotoxicity

Kopittke

2016

Plant Cell & Environment

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Elevated concentrations of soluble aluminium (Al) reduce root growth in acid soils, but much remains unknown regarding the toxicity of this Al as well as the mechanisms by which plants respond. This review examines changes in phytohormones in Al-stressed plants. Al often results in a rapid 'burst' of ethylene in root apical tissues within 15-30 min, with this regulating an increase in auxin. This production of ethylene and auxin seems to be a component of a plant-response to toxic Al, resulting in cell wall modification or regulation of organic acid release. There is also evidence of a role of auxin in the expression of Al toxicity itself, with Al decreasing basipetal transport of auxin, thereby potentially decreasing wall loosening as required for elongation. Increasingly, changes in abscisic acid in root apices also seem to be involved in plant-responses to toxic Al. Changes in cytokinins, gibberellins and jasmonates following exposure to Al are also examined, although little information is available. Finally, although not a phytohormone, concentrations of nitric oxide change rapidly in Al-exposed tissues. The information presented in this review will assist in focusing future research efforts in examining the importance of phytohormones in plant tissues exposed to toxic levels of Al.

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Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response

Cited by 96 publications

References 31 publications

SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration

SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration

DNA damage inhibits lateral root formation by up‐regulating cytokinin biosynthesis genes in Arabidopsis thaliana

Role of phytohormones in aluminium rhizotoxicity

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