Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrier

Ackley, David C.; Yokel, Robert A.

doi:10.1016/s0300-483x(97)03640-8

Cited by 37 publications

(17 citation statements)

References 27 publications

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“…Different candidates that may mediate Al-ci transport across the BBB have been proposed. Among them, the best are the monocarboxylate transporter (MCT) and an organic anion-transporting polypeptide (OATP) (73,78) . MCT1 has been found in rat brain microvessels on the luminal endothelial cell plasma membrane (79) .…”

Section: Brain Pathologymentioning

confidence: 99%

The meaning of aluminium exposure on human health and aluminium-related diseases

Crisponi

Fanni²,

Gerosa³

et al. 2013

BioMolecular Concepts

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Abstract:The aim of this review is to attempt to answer extremely important questions related to aluminiumrelated diseases. Starting from an overview on the main sources of aluminium exposure in everyday life, the principal aspects of aluminium metabolism in humans have been taken into consideration in an attempt to enlighten the main metabolic pathways utilised by trivalent metal ions in different organs. The second part of this review is focused on the available evidence concerning the pathogenetic consequences of aluminium overload in human health, with particular attention to its putative role in bone and neurodegenerative human diseases.

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Section: Brain Pathologymentioning

confidence: 99%

The meaning of aluminium exposure on human health and aluminium-related diseases

Crisponi

Fanni²,

Gerosa³

et al. 2013

BioMolecular Concepts

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“…These proton-coupled transporters mediate the concentrative uptake of essential anionic metabolites. They may also be involved in the influx and efflux of other compounds, such as aluminum citrate [39], probenecid [40] or benzoic acid [41].…”

Section: Organic Anion Transportersmentioning

confidence: 99%

Modulation of Drug Transporters at the Blood-Brain Barrier

Fricker

Miller

2004

Pharmacology

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A major challenge in the management of diseases of the central nervous system is the limited penetration of drugs into the brain. The structures responsible are the capillaries of the brain, whose endothelial cells form the so-called blood-brain barrier. Understanding the cellular and molecular structure as well as integrated function of this barrier is a prerequisite for successful drug delivery to the brain. Here we briefly review current knowledge about the active transport proteins (ABC and organic anion transporters) which function at the blood-brain barrier. We describe novel approaches to (1) modulate carrier protein function, and (2) circumvent the transporter-based carrier by targeted site-specific drug delivery systems, such as immunoliposome and nanoparticulate systems.

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“…The lack of SDCT2 mRNA in cerebral blood vessels or the choroid plexus suggests that SDCT2 is not involved in the transport of dicarboxylates across the blood-brain barrier. A recent study with perfused rat brain demonstrated that dicarboxylates are transported across the bloodbrain barrier through a transporter that is inhibited by monocarboxylates (32).…”

Section: Figurementioning

confidence: 99%

Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter

Chen

Tsukaguchi²,

Chen³

et al. 1999

J. Clin. Invest.

121

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Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrier

Cited by 37 publications

References 27 publications

The meaning of aluminium exposure on human health and aluminium-related diseases

The meaning of aluminium exposure on human health and aluminium-related diseases

Modulation of Drug Transporters at the Blood-Brain Barrier

Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter

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