Aluminum balance in intensive care patients

Wilhelm, Michael; Hoelzer, Juergen; Luebbers, K.; Stoehr, Gerhard A.; Ohmann, Christian

doi:10.1016/s0946-672x(01)80006-7

Cited by 12 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…man albumin have long been recognized as a source of Human toxicity to aluminum was reported in 1976 in aluminum contamination." Wilhelm et al 14 reported on several patients with chronic kidney disease who were re-aluminum balance in 15 critically ill patients. In this cliniceiving hemodialysis."…”

Section: Discussionmentioning

confidence: 99%

Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury

et al. 2008

View full text Add to dashboard Cite

show abstract

“…-patients with kidney and renal failure diseases are associated with the dialysis encephalopathy syndrome (Alfrey 1993;Yokel, 2000;Ward et al, 2001; EI-r-- Rahman et al, 2003) and bone related secondary ailments like osteodystrophy, osteoarthritis (Cassidy, 2003), and osteomalacia (Alfrey, 1976(Alfrey, , 1993Ott et a!., 1983). Another clinical exposure to Al is through intravenous solutions (Wilhelm et al, 2001). Sedman and colleagues (1985) reported elevated levels of this element in the bone, urine and plasma of premature infants who were undergoing intravenous therapy (Sedman et al, 1985;Bishop et al, 1989).…”

Section: Clinical Exposurementioning

confidence: 99%

Quantification of aluminum in human bone with neutron activation analysis

Davis¹

2021

Preprint

View full text Add to dashboard Cite

In Vivo Neutron Activation Analysis (IVNAA) has been investigated to measure aluminum levels in bone for several years. Aluminum, being a toxic element, should be routinely monitored in both clinical and occupational environments. The non-invasisve IVNAA technique developed at the McMaster University Accelerator Lab is currently being improved for future use. New sets of hand phantoms were prepared that closely resemble spectra that were collected from the hand of healthy subject. Following the IVNAA of aluminum phantoms, the technique was applied for the first time to measure bone A1 levels in 18 healthy subjects. The mean hand bone A1 concentration was determined as 28 µg A1/g Ca. The results were achieved with a dose equivalent of 17.6 mSv. Further investigations using an enhanced detection system and applying optimazation of the irradiation protocol with radiation dose up to 50 mSv showed that minimum detectable limit was improved to 0.10 mg A1.

show abstract

“…26 Additionally, in a study conducted by Poole et al, investigators found that meeting the new FDA regulation limiting aluminum administration to <5 µg/kg/day was not possible in patients who weighed <50 kg. 27 The same investigators later discovered that both measured and calculated levels were 3-5 times greater in neonatal PN than the limit set by the FDA.…”

Section: Aluminum Toxicity In Neonatal Parenteral Nutritionmentioning

confidence: 99%

“…A larger amount of calcium chloride must be used compared to calcium gluconate, which could result in an oversupplementation of chloride and subsequent metabolic acidosis. 26…”

Section: Barriers To Implementationmentioning

confidence: 99%

Aluminum Toxicity in Neonatal Parenteral Nutrition: What Can We Do?

Wier

Kuhn

2012

Ann Pharmacother

View full text Add to dashboard Cite

Aluminum toxicity has been described in patients of all ages who are receiving a variety of therapies, including dialysis, phosphate-binding medications, and parenteral nutrition (PN). Neonates are at an increased risk of aluminum toxicity because of anatomic, physiologic, and nutrition-related factors not present in other populations. In 2004, the Food and Drug Administration recommended restricting daily aluminum administration to 5 μg/kg/day and now requires that additives used to compound PN have the maximum aluminum content at expiration listed on the product label. Although the pharmacist can work to decrease aluminum toxicity in this population, it remains difficult to reach this threshold.

show abstract

Aluminum balance in intensive care patients

Cited by 12 publications

References 13 publications

Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury

Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury

Quantification of aluminum in human bone with neutron activation analysis

Aluminum Toxicity in Neonatal Parenteral Nutrition: What Can We Do?

Contact Info

Product

Resources

About