Aluminum and Silica Containing Porous Carrier for Active Pharmaceutical Ingredients

Мадонов, П. Г.; Popova, Tatyana V.; Rachkovskaya, L. N.; Мичурина, С. В.; Robinson, M. V.; Rachkovsky, Edmond; Ishchenko, I. Yu.; Лыков, А. П.; Shurlygina, A. V.; Повещенко, О. В.

doi:10.1109/sibircon48586.2019.8958448

Cited by 3 publications

(2 citation statements)

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“…The water absorption test was performed to determine which of the Ag-Si/Al 2 O 3 sorbents (1)(2)(3)(4) show the best absorption capability. Been a sorbent a substance which has the property of collecting molecules of another substance by sorption, and are commonly used as materials for blood purification and hemodialysis [53][54][55][56][57][58][59].…”

Section: Water Uptake Testmentioning

confidence: 99%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

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Section: Water Uptake Testmentioning

confidence: 99%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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“…С этой точки зрения представляет интерес использование биоцидного воздействия ионов меди и цинка в составе активных композиций [2][3][4]. Основой композиций могут выступать носители, характеризующиеся развитой системой пор, высокой удельной поверхностью и гидрофильно-гидрофобной химической природой поверхности [5]. Фундаментальные исследования подтвердили целесообразность использования модифицированных активными веществами сорбентов-носителей для целей детоксикации и доставки активных веществ в зону терапевтического действия [6].…”

Section: Introductionunclassified

Effect of Cu-, Zn-containing complex based on a porous matrix on fibroblast proliferation, apoptosis, necrosis and nitric oxide production

Лыков

Rachkovskaya

Повещенко

et al. 2021

Sibirskij nauchnyj medicinskij zhurnal

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A comparative study of the effect of a matrix based on porous aluminum oxide and a silicon organic polymer polydimethylsiloxane (PDMS) (А12O3@PDMS) and a matrix complex with copper and zinc sorbed on its surface (Cu@Zn- А12O3@PDMS) on the functional properties of fibroblasts has been carried out. Material and methods. The effect of the Cu@Zn- А12O3@PDMS complex and the matrix on the cell proliferative potential (MTT test), apoptosis, necrosis and the production of stable nitric oxide (NO) metabolites were studied in an in vitro experiment with a human embryo fibroblast cell line (HEF-15). Results. The compared samples of Cu@Zn-A12O3@PDMS and Al2O3@PDMS are similar in their physico-chemical properties. Study of HEF-15 functional potential indicates a higher level of cell proliferation and ability to produce NO after contact with the complex. There was no significant increase in apoptosis and necrosis of HEF-15 in the presence of samples of the complex and the carrier. Conclusion. The absence of a significant negative effect of the tested samples on the functional status of cells of the FEH-15 line (proliferation, apoptosis, necrosis, NO secretion) in vitro allows the use of the Cu@Zn-A12O3@PDMS complex for further analysis of its safety in experimental models of skin defects in animals.

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Biocompatability of the Complex Aluminum Oxide and Polydimethylsiloxane Modified with Carbon Nanofibre

Лыков

Rachkovskaya

Повещенко

et al. 2021

2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB)

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Aluminum and Silica Containing Porous Carrier for Active Pharmaceutical Ingredients

Cited by 3 publications

References 4 publications

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Effect of Cu-, Zn-containing complex based on a porous matrix on fibroblast proliferation, apoptosis, necrosis and nitric oxide production

Biocompatability of the Complex Aluminum Oxide and Polydimethylsiloxane Modified with Carbon Nanofibre

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