Aluminium phosphide ingestion.

Abstract

Patients with retinitis pigmentosa and neurological abnormalities detected on screening Case Age No (years) Clinical findings Group 1 (with deafness) 26* 65 Deaf, diminished vibration sense in feet, diminished ankle jerks 37 70 Deaf, old right cerebrovasculkr accident 42* 40 Deaf, anosmia, ataxia, diminished tendon jerks 45* 34 Deaf, mild ataxia Group 2 (withozut deafness) 1 60 Vertebrobasilar ischaemia 5* 39 Small pupils, absent ankle jerks 12 65 Myasthenia gravis 16 36 Right hemiparesis (mitral valve prolapse) 21 62 Dementia, epilepsy, spinocerebellar degeneration, red ragged myopathy 30 62 Disc prolapse L4-5, ulnar nerve palsy 40* 31 Ataxia, mild sensory neuropathy 44* 59 Diminished peripheral sensation, diminished ankle jerks 46 11 Laurence-Moon-Biedl syndrome 55 16 Congenital sensory neuropathy *Clinical suspicion of heredopathia atactica polyneuritiformis. deteriorating retinitis pigmentosa, and deafness. She had suffered an acute episode of ataxia after a viral illness. Examination showed pes cavus, anosmia, retinitis pigmentosa, small reacting pupils, nerve deafness, wasting of the small muscles of the hands, diminished tendon reflexes, and reduced sensation in the feet. She was ataxic on heel and toe walking and coordination was poor in all limbs. Nerve conduction studies disclosed a mild sensory and motor polyneuropathy. The plasma phytanic acid concentration (1-1 mmol/l; 34 mg/100 ml) declined to 0-2 mmol/l (7 mg/100 ml) with a low phytanic acid diet.4 Comment I Wilson JK, Hammond JJ, Kirkendall WM. The captopril induced eruption.

Aluminium Phosphide Poisoning

“…It was present in 12 out of 92 cases and was said to be common in another series of 15 patients (Singh, et al, 1985) but confirmatory laboratory data were not provided. Jaundice was alleged to be present in 16 (52%) members of the crew of a grain freighter who inhaled phosphine after an accidental release but, in the six tested, serum bilirubin concentrations were normal and transaminase activities only minimally disturbed, casting doubt on the clinical observation.…”

Fosfina: Riscos

“…As formulações comerciais do fosfeto de alumínio contêm geralmente de 55 a 75% de princípio ativo e são vendidos na forma de comprimidos (SINGH et al, 1985;ANGER, 2000) e pílulas (SINGH et al, 1985), como, por exemplo, Phosphinon ® (ANGER, 2000), Celphos SINGH et al, 1985;KOSLA, 1988). O fosfeto de zinco é comercializado no exterior como: Arrex…”

Cardiovascular profile of aluminium phosphide poisoning and its clinical significance

“…Hemodialysis was given to one patient who developed acute renal failure and the patient survived. 11 Laha NN et al have supported use of magnesium sulphate. Early induction of vomiting with injection magnesium sulphate (1 ampoule of 20%, 2 ml 6 hours) led to good prognosis and mortality is reduced from previous 100% to 37%.…”

“…Early induction of vomiting with injection magnesium sulphate (1 ampoule of 20%, 2 ml 6 hours) led to good prognosis and mortality is reduced from previous 100% to 37%. 11,12 Treatment was mainly with hydrocortisone. Injection digoxin was used if no arrhythmias were there.…”