Aluminium concentrations in the brain and bone of rate fed citric acid, aluminium citrate or aluminium hydroxide

Slanina, Premysl; Falkeborn, Y.; Frech, Wolfgang; Cedergren, Anders

doi:10.1016/0278-6915(84)90369-7

Cited by 167 publications

(62 citation statements)

References 26 publications

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“…In a more recent study, Weberg & Berstad (1986) estimated from changes in urinary Al excretion that Al absorption from antacids taken with water by normal volunteers was less than 0.1 YO, while Al absorption from antacids taken with citrate could be as high as 0 7 %. Slanina et al (1984Slanina et al ( , 1986) also demonstrated that citrate enhances intestinal Al absorption in animals and humans.…”

Section: Oral-enteral a D M I N I S T R A T I O N Absorptionmentioning

confidence: 97%

Nutritional Aspects of Aluminium Toxicity

Klein

1990

Nutr. Res. Rev.

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Table 1. Parenteral sources of aluminium contamination A1 Wl) Source Casein hydrolysate (100 g/l) Crystalline amino acids (100 g/l) Potassium phosphate (3 mmol/l) Unspecified phosphate Potassium phosphate Potassium acid phosphate (136 g/l) Sodium phosphate (3 mmol/l) Calcium gluconate (100 g/l) Calcium glucoheptonate Normal serum albumin (250 g/l) Normal serum albumin (43 g/l) Plasmanate? (50 g/l) Heparin (lo00 u/ml) Factor VIII Factor IX Trace metal solutions Multivitamin infusion

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Section: Oral-enteral a D M I N I S T R A T I O N Absorptionmentioning

confidence: 97%

Nutritional Aspects of Aluminium Toxicity

Klein

1990

Nutr. Res. Rev.

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“…in DES (Dialysis Encephalopathy Syndrome) (8,9,10,11,12). In experimental animals serum, bone and brain levels may be increased after oral administration of aluminium compounds (13,15). Intoxication has been reported in wild animals (2, 3) and plants (4).…”

Section: Discussionmentioning

confidence: 99%

Aluminium intoxication in a dog

Toor¹,

Voet

Ellen³

et al. 1990

Veterinary Quarterly

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SUMMARY.A two-year-old male Barsoi dog was presented after a two-week period of muscle twitching and convulsions during exercise, which worsened to a state of tetraparesis and coma.Removal of a gastric foreign body, containing aluminium, resolved the presenting signs.Parallel with this clinical recovery the elevated serum levels of aluminium decreased to values of two normal control dogs, suggesting that the neurological signs were due to A l intoxication.

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“…One factor that may be of importance for aluminum uptake is the simultaneous administration of citrate. It has been shown in rats that citrate increased intestinal aluminum uptake with subsequent increases in cerebral and bone aluminum concentrations (65). However, considerably more information is needed for an understanding of the conditions under which aluminum can be absorbed from the gastrointestinal tract and accumulated in tissues.…”

Section: Aluminum Adverse Health Effects Of Aluminum Exposuresmentioning

confidence: 99%

Impact of effects of acid precipitation on toxicity of metals.

Nordberg¹,

Goyer²,

Clarkson³

1985

Environ Health Perspect

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Acid precipitation may increase human exposure to several potentially toxic metals by increasing metal concentrations in major pathways to man, particularly food and water, and in some instances by enhancing the conversion of metal species to more toxic forms.Human exposures to methylmercury are almost entirely by way of consumption of fish and seafood. In some countries, intakes by this route may approach the levels that can give rise to adverse health effects for population groups with a high consumption of these food items. A possible increase in methylmercury concentrations in fish from lakes affected by acid precipitation may thus be of concern to selected population groups.Human exposures to lead reach levels that are near those associated with adverse health effects in certain sensitive segments of the general population in several countries. The possibility exists that increased exposures to lead may be caused by acid precipitation through a mobilization of lead from soils into crops. A route of exposure to lead that may possibly be influenced by acid precipitation is an increased deterioration of surface materials containing lead and a subsequent ingestion by small children. A similar situation with regard to uptake from food exists for cadmium (at least in some countries).Human metal exposures via drinking water may be increased by acid precipitation. Decreasing pH increases corrosiveness of water enhancing the mobilization of metal salts from soil; metallic compounds may be mobilized from minerals, which may eventually reach drinking water. Also, the dissolution of metals (Pb, Cd, Cu) from piping systems for drinking water by soft acidic waters of high corrosivity may increase metal concentrations in drinking water. Exposures have occasionally reached concentrations which are in the range where adverse health effects may be expected in otherwise healthy persons. Dissolution from piping systems can be prevented by neutralizing the water before distribution.Increased aluminum concentrations in water is a result mainly of the occurrence of Al in acidified natural waters and the use of Al chemicals in drinking water purification. If such water is used for dialysis in patients with chronic renal failure, it may give rise to cases of dialysis dementia and other disorders. A possible influence on health of persons with normal renal function (e.g., causing Alzheimers disease) is uncertain and requires further investigation.While all of the mentioned possibilities for increased metal exposures due to acid precipitation do exist, information that allows a quantitative estimation of their importance is almost entirely lacking and more research is needed.For an evaluation of the impact to human health of increased metal exposures, present knowledge about relationships between dose (or exposure) and the risk for adverse effects are reviewed. It is concluded that improved knowledge would be desirable for several of the metals discussed. Particularly, for an evaluation of possible adverse effects of aluminum in pers...

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Aluminium concentrations in the brain and bone of rate fed citric acid, aluminium citrate or aluminium hydroxide

Cited by 167 publications

References 26 publications

Nutritional Aspects of Aluminium Toxicity

Nutritional Aspects of Aluminium Toxicity

Aluminium intoxication in a dog

Impact of effects of acid precipitation on toxicity of metals.

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