Aluminium administration is associated with enhanced hepatic oxidant stress that may be offset by dietary vitamin E in the rat

Abstract

Summary. It has been proposed that aluminium toxicity may be mediated, at least in part, by free radical generation. We have investigated the effects of aluminium lactate administration on indices of hepatic oxidant stress, and the consequences of concomitant dietary vitamin E, in male albino Wistar rats. Aluminium lactate was administered for 4 weeks, by ip injection at 10 mg aluminium/kg body weight. Groups of animals received a chow diet containing 0, 5, 15, or 20 mg vitamin E/g of food. A control group of rats received a normal chow diet, without being injected with aluminium. The rats were killed after 4 weeks, and blood and liver tissue removed for the measurement of aluminium and markers of oxidative stress. Plasma and liver aluminium levels were increased in all groups of animals receiving aluminium lactate (P < 0.01), although these levels were significantly reduced in rats receiving concomitant vitamin E (P < 0.05). Aluminium treatment was associated with significantly increased levels of hepatic reactive oxygen species (ROS) (P < 0.01) that were attenuated by concomitant vitamin E (P < 0.05). Hepatic catalase and reduced glutathione levels were both reduced in animals treated with aluminium (P < 0.05).

Evaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats

“…1,21 Experimental animal models and cell culture studies reveal that aluminum affects the expression of SOD, CAT, GSH peroxidase and GSH possibly leading to membrane fragility as a consequence. 25 SOHE treatment decrease the TBARS level and restored the antioxidant levels in Liver, kidney, lungs and heart of aluminum treated animals. Kumaran & Karunnakaran, 2007 reported that, alkaloids have also been reported to strongly inhibit LPO induced in isolated tissues through its antioxidant activity.…”

Histopathological Changes in Rat Liver After A Single High Dose of Aluminium

“…On the other hand, Abubakar et al (16) ascertained that Al in hepatocytes, even in small quantities, is associated with an increase in reactive oxygen species and lipid peroxidation. Gonzales et al (5) pointed out a hepatocyte dysfunctionin terms of reduced in the liver.…”

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

“…These include vitamins, fatty acids and antibody (Edenharder et al 1999;Rao et al 2001;Yoshida et al 2010;Turkez et al 2012b). Concomitant treatment with the anti-oxidants provided protection against oxidative damage by mutagens in experimental animals (Abubakar et al 2003;Esparza et al 2003;Geyikoglu et al 2005;. To our best knowledge, no investigation on the anti-genotoxicity potential of X. elegans extracts (XEEs) on mitomycin C (MMC)-induced cytotoxicity in human blood cells was reported in the literature.…”