Aluminium-26 as a Biological Tracer using Accelerator Mass Spectrometry

Flarend, Richard; Elmore, D.

doi:10.1142/9789812817174_0002

Cited by 8 publications

(6 citation statements)

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“…4 Hence, looking on the potential impact of Al 3+ ions on human health, the detection of Al 3+ has attracted increasing interest in the areas of chemical and biological sciences, particularly, to 60 monitor the concentration levels in the biosphere and to minimize direct affects on human health. A number of techniques available for Al 3+ estimation include chromatography 7 , accelerator mass spectroscopy (AMS) 8 , graphite furnace atomic absorption spectrometry (GFAAS) 9 , neutron activation being a hard-acid prefers a hard coordination sphere of N and O donor atoms. 17,28 Not only that most of the reported Al 3+ -sensors involve complicated synthetic routes with harsh reaction conditions and expensive chemicals.…”

Section: Introductionmentioning

confidence: 99%

Retracted Article: A simple rhodamine-based dual signalling reversible molecular switch for recognition of Al(III) with Promising applications for advanced logic operations – ‘OR’, ‘Keypad Lock’ & ‘INHIBIT’ logic function and cell-imaging studies†.

Mahammad¹,

Mistri²,

Alam³

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Retracted Article: A simple rhodamine-based dual signalling reversible molecular switch for recognition of Al(III) with Promising applications for advanced logic operations – ‘OR’, ‘Keypad Lock’ & ‘INHIBIT’ logic function and cell-imaging studies†.

Mahammad¹,

Mistri²,

Alam³

et al. 2014

Analyst

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“…In this study, the use of 26 Al, which is not present in the environment or in normal biological organisms, was incorporated as a tracer in the oral dose (tea infusion). The use of 26 Al to study Al toxicokinetics was reviewed (Flarend and Elmore, 1998). 26 Al was analyzed by accelerator mass spectrometry (AMS), which measures the 26 Al/ 27 Al ratio with a detection limit of ~ 1,000,000 26 Al atoms.…”

Section: Introductionmentioning

confidence: 99%

Aluminum bioavailability from tea infusion

Yokel

Florence

2008

Food and Chemical Toxicology

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The objective was to estimate oral Al bioavailability from tea infusion in the rat, using the tracer 26Al. 26Al citrate was injected into tea leaves. An infusion was prepared from the dried leaves and given intra-gastrically to rats which received concurrent intravenous 27Al infusion. Oral Al bioavailability (F) was calculated from the area under the 26Al, compared to 27Al, serum concentration × time curves. Bioavailability from tea averaged 0.37%; not significantly different from water (F = 0.3%), or basic sodium aluminum phosphate (SALP) in cheese (F = 0.1 to 0.3%), but greater than acidic SALP in a biscuit (F = 0.1%). Time to maximum serum 26Al concentration was 1.25, 1.5, 8 and 4.8 h, respectively. These results of oral Al bioavailability × daily consumption by the human suggest tea can provide a significant amount of the Al that reaches systemic circulation. This can allow distribution to its target organs of toxicity, the central nervous, skeletal and hematopoietic systems. Further testing of the hypothesis that Al contributes to Alzheimer's disease may be more warranted with studies focusing on total average daily food intake, including tea and other foods containing appreciable Al, than drinking water.

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“…The natural abundance of 26 Al is extremely small. 26 Al can be quantified with exquisite sensitivity (~1 × 10 6 atoms) as the 26 Al: 27 Al isotopic ratio by accelerator mass spectrometry (AMS), enabling the study of Al toxicokinetics at physiologically relevant Al exposures (40). A disadvantage is the cost of AMS analysis of 26 Al (~$200/sample).…”

Section: Some Aluminum Persists In the Brain For A Long Timementioning

confidence: 99%

Brain uptake, retention, and efflux of aluminum and manganese.

Yokel

2002

Environ Health Perspect

113

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My colleagues and I investigated the sites and mechanisms of aluminum (Al) and manganese (Mn) distribution through the blood-brain barrier (BBB). Microdialysis was used to sample non-protein-bound Al in the extracellular fluid (ECF) of blood (plasma) and brain. Brain ECF Al appearance after intravenous Al citrate injection was too rapid to attribute to diffusion or to transferrin-receptor-mediated endocytosis, suggesting another carrier-mediated process. The brain:blood ECF Al concentration ratio was 0.15 at constant blood and brain ECF Al concentrations, suggesting carrier-mediated brain Al efflux. Pharmacological manipulations suggested the efflux carrier might be a monocarboxylate transporter (MCT). However, the lack of Al 14 C-citrate uptake into rat erythrocytes suggested it is not a good substrate for isoform MCT1 or for the band 3 anion exchanger. Al 14 C-citrate uptake into murine-derived brain endothelial cells appeared to be carrier mediated, Na independent, pH independent, and energy dependent.

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Aluminium-26 as a Biological Tracer using Accelerator Mass Spectrometry

Cited by 8 publications

References 0 publications

Retracted Article: A simple rhodamine-based dual signalling reversible molecular switch for recognition of Al(III) with Promising applications for advanced logic operations – ‘OR’, ‘Keypad Lock’ & ‘INHIBIT’ logic function and cell-imaging studies†.

Retracted Article: A simple rhodamine-based dual signalling reversible molecular switch for recognition of Al(III) with Promising applications for advanced logic operations – ‘OR’, ‘Keypad Lock’ & ‘INHIBIT’ logic function and cell-imaging studies†.

Aluminum bioavailability from tea infusion

Brain uptake, retention, and efflux of aluminum and manganese.

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