Alu Methylation Patterns in Type 1 Diabetes: A Case-Control Study
Andromachi Katsanou,
Charilaos A. Kostoulas,
Evangelos Liberopoulos
et al.
Abstract:Evidence suggests that genome-wide hypomethylation may promote genomic instability and cellular senescence, leading to chronic complications in people with diabetes mellitus. Limited data are however available on the Alu methylation status in patients with type 1 diabetes (T1D). Methods: We investigated DNA methylation levels and patterns of Alu methylation in the peripheral blood of 36 patients with T1D and 29 healthy controls, matched for age and sex, by using the COmbined Bisulfite Restriction Analysis meth… Show more
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