Altred Fructosamine and Lipid Fractions in Subclinical Hypothyroidism

Udupa, Sridevi V; Manjrekar, Poornima; Udupa, Vinit A.; D’Souza, Vivian

doi:10.7860/jcdr/2012/5011.2660

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…We excluded patients with thyroid disorders because serum protein turnover is lower in hypothyroidism and higher in hyperthyroidism, which leads to increased and decreased protein glycation respectively. 29 , 30 We also excluded patients with protein-losing disorders. Hence, the rates of serum protein turnover and glycation in the study participants were likely to be occurring at steady states.…”

Section: Discussionmentioning

confidence: 99%

Fructosamine and HbA1c A: Correlational Study in a Southeast Asian Population

Chandran,

Lee,

Shen

et al. 2024

JAFES

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Objectives. Fructosamine correlates well with glycated haemoglobin (HbA1c) in Caucasians. This study investigates this correlation and whether fructosamine can reliably estimate glycated haemoglobin in Southeast Asians.Methods. We recruited 193 participants based on 4 HbA1c bands (<6.0%; 6.0 -7.9%; 8.0-9.9%; ≥10%) from a secondary hospital in Singapore between August 2017 and December 2021. Blood samples for fructosamine, glycated haemoglobin, albumin, haemoglobin, thyroid stimulating hormone and creatinine were drawn in a single setting for all participants. Scatter plot was used to explore correlation between fructosamine and glycated haemoglobin. Strength of linear correlation was reported using Pearson's correlation coefficient. Simple linear regression was used to examine the relationship between fructosamine and glycated haemoglobin.Results. We performed simple linear regression to study the relationship between fructosamine and HbA1c in the research participants (R 2 = 0.756, p<0.01). Further analysis with natural logarithmic transformation of fructosamine demonstrated a stronger correlation between HbA1c and fructosamine (R 2 = 0.792, p<0.01).Conclusions. Fructosamine is reliably correlated with HbA1c for the monitoring of glycaemic control in Southeast Asians.

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Section: Discussionmentioning

confidence: 99%

Fructosamine and HbA1c A: Correlational Study in a Southeast Asian Population

Chandran,

Lee,

Shen

et al. 2024

JAFES

View full text Add to dashboard Cite

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“…Glycated proteins accumulation in tissues will resist minor proteolysis and become other free radicals source ( 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Changes of Certain Metabolic and Cardiovascular Markers Fructosamine, H-FABP and Lipoprotein (a) in Patients with Hypothyroidism

2021

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Background: Disorders of thyroid gland are common in general population, and it’s the most common affecting the endocrine system after diabetes mellitus. Thyroid function regulates a wide range of metabolic parameters, as well as affects some cardiovascular disease risk factors. Fructosamine is produced by a reaction between albumin (protein) and glucose; it is used to monitor patients with diabetes for short-term glycemic changes. H-FABP is present in the cytoplasm of cardiac myocytes, and delivers fatty acids into these cells. It has been shown to increase in myocardial injury. Lipoprotein LP(a) is consist of a special apolipoprotein called apoprotein (a), and it’s recognized as a cardiovascular disease independent risk factor. Objective: To study whether certain metabolic and cardiovascular markers (fructosamine, H-FABP and lipoprotein (a) are changed in hypothyroid patients. Methods: The current study included 280 overt hypothyroid, 272 with subclinical hypothyroidism compared with 270 healthy individuals of matched age and gender. For all subjects serum (TSH, T4, T3, FBS, HbA1c, fructosamine, triglycerides, cholesterol, lipoprotein (a), and Heart-type Fatty Acid-Binding Protein (H-FABP)) was measured. Results: Serum fructosamine level significantly elevated (p value <0.05) in patient with hypothyroidism when compared with control group, and no significant change between subclinical and control groups. There is no significant change in serum H-FABP between study subjects. There is significant increase in lipoprotein (a) in patient with hypothyroidism and those with subclinical group when compared with control group. Conclusion: Serum fructosamine and level is significantly changed in patients with overt hypothyroidism when compared with euthyroid subjects. Also, we conclude that hypothyroidism increase risk of cardiovascular diseases by changing non-traditional marker such as lipoprotein (a), and no effect on H-FABP concentration.

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“…BMI is also negatively associated with fructosamine in those without diabetes and falls during pregnancy , further complicating its interpretation. Thyroid status may affect fructosamine interpretation , however, not necessarily independently of deranged glucose and protein metabolism .…”

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confidence: 98%