Altitude effect on Propofol Pharmacokinetics in Rats
Lijun Li,
Xuejun Wang,
Sheng Wang
et al.
Abstract:Background::
Propofol is an intravenous agent for clinical anesthesia. As the influence of the hypobaric-
hypoxic environment (Qinghai-Tibetan region, altitude: 2800-4300 m, PaO2: 15.1-12.4 kPa) on the
metabolism of Propofol is complex, the research results on the metabolic characteristics of Propofol in high-
-altitude areas remain unclear. This study aimed to investigate the pharmacokinetic characteristics of Propofol
in a high-altitude hypoxic environment using animal experiments.
Methods::
Rats were rand… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.