Alternatives of Human Organ/Tissue Transplantation

Bhattacharya, Niranjan; Stubblefield, Phillip G.

doi:10.1007/978-1-4471-4171-6_1

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With recent advancement in life sciences technologies, novel tools are available to investigate the potential of cell therapy for many neurological disorders mentioned above both in vitro and in vivo (Morimoto et al, 2013;Bhattacharya and Stubblefield, 2013;Tajiri et al, 2014b;Liang et al, 2016). In order to develop safe and effective cell therapy methods that can be translated to clinical application, it is important to understand the complex underlying pathologies of these diseases, particularly with aging as a contributing factor.…”

Section: Stem Cell Applications For Aging and Neurological Disordersmentioning

confidence: 99%

Stem cell therapy for neurological disorders: A focus on aging

Nguyen

Zarriello

Coats

et al. 2019

Neurobiology of Disease

View full text Add to dashboard Cite

Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options.

show abstract

Section: Stem Cell Applications For Aging and Neurological Disordersmentioning

confidence: 99%