Alternatively spliced, germline Jα11-2-Cα mRNAs are the predominant T cell receptor α transcripts in mouse kidney

Madrenas, Joaquı́n; Vincent, Dianne H.; Kriangkum, Jitra; Elliott, John F.; Halloran, Philip F.

doi:10.1016/0161-5890(94)90094-9

Cited by 2 publications

(3 citation statements)

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“…Thus, TCR encoded transcripts are not unique to T cells and apparently the TCR gene family may have much broader expression and function ranges than previously realised. TCR transcripts have also been reported in additional cell lineages; TCRa mRNA has been identi®ed in murine kidney (Madrenas et al, 1991(Madrenas et al, , 1992(Madrenas et al, , 1994. In a recent study, no evidence for TCRab or TCRd transcripts or proteins was found in epithelial tumor cells, whereas, a partial TCRg chain mRNA, lacking the V region was detected.…”

Section: Discussionmentioning

confidence: 93%

The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control

et al. 2002

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The mesenchyme plays a crucial regulatory role in organ formation and maintenance. However, comprehensive molecular characterization of these cells is lacking. We found unexpectedly that primary mesenchyme, as well as mesenchymal cell clones, express T cell receptor (TCR)ab mRNAs, lacking the variable region. Immunological and genetic evidence support the expression of a corresponding TCRb protein. Additionally, mRNAs encoding TCR complex components including CD3 and z chain are present. A relatively higher expression of the mesenchymal TCRb mRNA by cultured mesenchymal cell clones correlates with fast growth, whereas poorly expressing cells are slow growers and are contact inhibited. The clones that express relatively higher amount of the TCR mRNA exhibit an increased capacity to form tumors in nude mice. However, the expression of this mRNA in the mesenchyme is not per se leading to tumorigenesis, as demonstrated by primary mesenchyme that does not form tumors in mice while expressing moderate amounts of the TCR transcripts. The expression of mesencymal TCRb was con®ned to the G2/M phases of the cell cycle in the MBA-13 mesenchymal cell line. This cell cycle dependent expression, considered together with the correlation between growth properties and the level of TCR expression by cell clones, implies association of mesenchymal TCR with cell growth control.

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Section: Discussionmentioning

confidence: 93%

The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control

et al. 2002

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“…In the mouse, it has been shown that transcripts conceptually and functionally similar to TARP originate from the TCRA and TCRB gene in mesenchymal cells (Barda-Saad et al, 2002). Similar findings were reported for mouse cells of epithelial (kidney) origin (Madrenas et al, 1992(Madrenas et al, , 1994.…”

Section: Introductionmentioning

confidence: 50%

“…Murine mesenchymal cell lines express truncated TCRA and TCRB mRNA composed of J segment correctly spliced to C region, but lacking V region sequences (Barda-Saad et al, 2002). Similarly, partial TCRA J -C transcripts were detected in murine kidney (Madrenas et al, 1992(Madrenas et al, , 1994. In humans, prostate and breast tissue TCRG transcripts are also truncated, lacking V regions (Essand et al, 1999).…”

Section: Discussionmentioning

confidence: 93%

Expression of T cell receptor alpha gene (TCRA) in human rhabdomyosarcoma and other musculo-skeletal sarcomas

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et al. 2005

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Alternatively spliced, germline Jα11-2-Cα mRNAs are the predominant T cell receptor α transcripts in mouse kidney

Cited by 2 publications

References 42 publications

The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control

The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control

Expression of T cell receptor alpha gene (TCRA) in human rhabdomyosarcoma and other musculo-skeletal sarcomas

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