Alternative to antibiotics for managing asymptomatic and non-symptomatic bacteriuria in older persons: a review

Abstract

Recurrent urinary tract infection (UTI) is one of the most common reasons for long-term antibiotic use in frail older people, and these individuals often have non-symptomatic bacteriuria. This article reviews the literature and recommendations for the treatment of UTIs particularly in the older population (>65 years). It considers the question: is there an alternative for antibiotics for asymptomatic and non-symptomatic bacteriuria in older adults? D-mannose powder has been recommended for the treatment of UTIs, as when applied locally, it reduces the adherence of Escherichia coli. In one study, D-mannose was reviewed for the prophylaxis of recurrent UTIs in women, and the findings indicated that it may be useful for UTI prevention instead of prophylactic antibiotics. There is a lack of information about the efficacy of cranberry products combined with D-mannose in this regard, and this is an area for further research.

Anthocran® Phytosome®: Prevention of Recurring Urinary Infections and Symptoms after Catheterization

“…Supplement studies are aimed to define the field of activity of pharmaceutical standard (PS) supplements and possible preventive, preferably non-severe conditions (9,10,23). These studies are designed and organized with the full attention and participation of the evaluated subjects.…”

“…in case the syndrome has a considerable impact on people's lives, as in immunocompromised subjects, in younger, active, working subjects; or conversely, if it may be less important -i.e. in older subjects spending most of their time at home (4,9,10).…”

Deep insights into urinary tract infections and effective natural remedies

“…So, the use of the sugar or its analogs can help to block the adhesion of E. coli to the bladder epithelium. The efficacy of these sugars in controlling UTI has been studied previously [96][97][98].…”

Alternative Management of Uncomplicated UTIs in Women

“…D-mannose can be an effective aid in acute cystitis management and also a successful prophylactic agent in a selected population [60][61][62]. Duncan et al [63] reported that it may be useful for UTI prevention instead of prophylactic antibiotics, which was no different than in Nitrofurantoin group [64]. While research has proven this to be effective, there is a risk that long-term antibiotic use will increase the likelihood of bacteria becoming resistant to antibiotics.…”