Alternative Technologies to Improve Solubility and Stability of Poorly Water-Soluble Drugs

Júnior, Walter Ferreira da Silva; Pinheiro, Jonas Gabriel de Oliveira; Moreira, Carlos D.L.F.A.; Souza, Fabia J.J. de; Lima, Ádley Antonini Neves de

doi:10.1016/b978-0-323-52725-5.00015-0

Cited by 33 publications

(14 citation statements)

References 182 publications

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“…Synthesized materials were indicated advantages over natural materials since they have reproducible quality and purity. In addition, they can be tuned with different chemical ionic, mechanical, solubility and degradability properties, adjusted according to the different pharmaceutical applications [ 56 ].…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

“…Additionally, Eudragit ® polymers are a series of synthetic polymers with different ratios of acrylate and methacrylate portions, and are used as coating materials for various kinds of dosage forms in pharmaceutical applications due to their biocompatibility, biodegradability and flexible ionic properties [ 56 ]. Eudragit ® polymers have been considered for the formulation of nanocapsules shell.…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…HPMC and SA have been decided as the bioadhesive polymers to be used in the development of the formulation. Due to its good biocompatibility and biodegradability along with wide availability and ease of use [ 36 ], HPMC has been a popular ingredient as a drug delivery matrix in the form of a film or gel for controlling the release of both hydrophilic and hydrophobic drugs [ 37 ]. A study had also been concluded that Pluronics are compatible to develop a safe and stable temperature-based in situ gelling system with bioadhesive properties when combined with HPMC [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

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Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

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“…CBDVA and CBGA, which migrated after 30 min of analysis time, in the presence of βCD, started to migrate around 14 and 17 min, respectively ( Figure S3). Fully non-aqueous electrolyte was not feasible since βCD was not soluble in the absence of water [22].…”

Section: Methodsmentioning

confidence: 99%

Single-Run Separation and Quantification of 14 Cannabinoids Using Capillary Electrophoresis

et al. 2021

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Quantification of major cannabinoids in cannabis products is normally performed using high-pressure liquid chromatography (HPLC)-based methods. We propose a cost-effective alternative method that successfully separates and quantifies 14 cannabinoids in a single run using capillary electrophoresis (CE) coupled with a UV detector in 18 min. The separation is carried out in 60% acetonitrile in the presence of 6.5 mM sodium hydroxide and 25 µM β-cyclodextrin, resulting in good separation of cannabinoids. Our CE method demonstrated the limit of detection between 1.2–1.8 µg/mL, with the linear range reaching up to 50 µg/mL. We validated the method performance by testing a plant extract and quantifying cannabinoid content. This method is the first to separate 14 cannabinoids in one run using a CE system with UV detection.

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Alternative Technologies to Improve Solubility and Stability of Poorly Water-Soluble Drugs

Cited by 33 publications

References 182 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Single-Run Separation and Quantification of 14 Cannabinoids Using Capillary Electrophoresis

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