Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

RHBDF1 modulates cisplatin sensitivity of small cell lung cancer through YAP1/Smad2 signaling pathway

“…To further elucidate the specific mechanism of RHBDF1 regulating the biological behaviors of SCLC, RHBDF1 and its co-expressed genes from our previous RNA sequencing results in SCLC [ 5 , 6 ] were performed for functional enrichment analysis. Gene ontology (GO) analysis showed that RHBDF1 was mainly involved in various biological processes (BP), including RNA splicing, nuclear transport, RNA localization, protein acylation, and dephosphorylation ( Fig.…”

“…We determined our previous RNA sequencing results [ 5 , 6 ] and found that YAP1 was highly expressed in drug-resistant patients with SCLC compared with drug-sensitive patients with SCLC ( Fig. 3 A).…”

“…The functional enrichment analysis of RHBDF1 and its co-expressed genes was performed using our previous RNA sequencing data [ 5 , 6 ]. We found that RHBDF1 was related to proteasome and ubiquitination.…”

“…Based on the present treatment strategies, we detected that human rhomboid-5 homolog-1 (RHBDF1) was differentially expressed in SCLC tissues of 5 intrinsic cisplatin-resistance and 5 intrinsic cisplatin-sensitivity by RNA sequencing [ 5 , 6 ]. RHBDF1 is a multi-transmembrane protein mainly located in the Golgi membrane and endoplasmic reticulum membrane [ 7 , 8 ].…”

Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy

“…IRhom proteins have seven transmembrane domains and are predominantly localized in endoplasmic reticulum (ER) 6 but also distributed on the route of protein trafficking, including Golgi and cell surface 7,8 . They have been shown to regulate (enhance) the activity of ADAM17, a membrane-tethered metalloprotease and the primary shedding enzyme responsible for the release of the proinflammatory cytokine TNFα and several EGF receptor ligands 6,[9][10][11][12] . IRhom proteins are also found to be involved in regulating the homeostasis and functions of other proteins such as HIF1α and JNK2/ 3 7,13,14 .…”