Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats
Nelly Mak,
Dan Zhang,
Xiaomeng Li
et al.
Abstract:The interferon response is shaped by the evolutionary arms race between hosts and the pathogens they carry. The human interferon-induced transmembrane protein (IFITM) family consists of three antiviralIFITMgenes that arose by gene duplication, they restrict virus entry and are key players of the interferon response. Yet, little is known about IFITMs in other mammals. Here, we identified anIFITMgene in Chinese horseshoe bat, a natural host of SARS-coronaviruses, that is alternatively spliced to produce two IFIT… Show more
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