Alternative proteoforms and proteoform-dependent assemblies in humans and plants
Claire D McWhite,
Wisath Sae-Lee,
Yaning Yuan
et al.
Abstract:The variability of proteins at the sequence level creates an enormous potential for proteome complexity. Exploring the depths and limits of this complexity is an ongoing goal in biology. Here, we systematically survey human and plant high-throughput bottom-up native proteomics data for protein truncation variants, where substantial regions of the full-length protein are missing from an observed protein product. In humans, Arabidopsis, and the green alga Chlamydomonas, approximately one percent of observed prot… Show more
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