2017
DOI: 10.1016/j.devcel.2017.08.008
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Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts

Abstract: SUMMARY Organogenesis during embryonic development occurs through the differentiation of progenitor cells. This process is extraordinarily accurate, but the mechanisms ensuring high fidelity are poorly understood. Coronary vessels of the mouse heart derive from at least two progenitor pools, the sinus venosus and endocardium. We find that the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors. Because they do not depend on ELA-APJ, endocardial progenitors are able to expand… Show more

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Cited by 87 publications
(109 citation statements)
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References 44 publications
(101 reference statements)
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“…Therefore, our data collectively support the idea that Ccbe1 is first expressed in the epicardium and then secreted into the ventricular surface, where it participates in the functional maturation of VEGF‐C propeptides. Our results confirm the data reported by Sharma et al () and also show evidence of the requirement of CCBE1 for VEGF‐C–dependent signaling during the development of SV endocardium–derived coronary vessels.…”
Section: Discussionsupporting
confidence: 93%
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“…Therefore, our data collectively support the idea that Ccbe1 is first expressed in the epicardium and then secreted into the ventricular surface, where it participates in the functional maturation of VEGF‐C propeptides. Our results confirm the data reported by Sharma et al () and also show evidence of the requirement of CCBE1 for VEGF‐C–dependent signaling during the development of SV endocardium–derived coronary vessels.…”
Section: Discussionsupporting
confidence: 93%
“…Cell‐tracing analysis suggests that coronary endothelium arises from three different progenitor populations: the sinus venosus (SV) endocardium (Red‐Horse et al, ; Chen et al, ), the ventricular endocardium (Wu et al, ), and the proepicardium (Katz et al, ; Cano et al, ). Regarding the contribution of each progenitor to the heart, lineage‐tracing experiments using Apj CreER (SV‐derived) (Chen et al, ), Nfatc1 Cre (endocardial‐derived) (Wu et al, ; Sharma et al, ), and Sema3D Cre and G2‐ Gata4 Cre (proepicardial‐derived) (Katz et al, ; Cano et al, ) showed that SV endocardium–derived ECs populate mainly the dorsal and right lateral sides, ventricular endocardium–derived vessels cover the ventral side, and the epicardial‐derived populate uniformly and intramyocardially through the ventricular wall. Despite this controversy, a consensus exists on the importance of the scaffolding role played by SV endocardium–derived primitive blood vessels during early coronary development.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the proepicardial endothelium is continuous with the sinus venosus endothelium, which also contributes to vascular endothelial cells in the liver (Niderla-Bielinska et al, 2015;Zhang et al, 2016). Finally, there is evidence that endothelial progenitor pools can compensate for each other (Sharma, Ho, et al, 2017). It is possible that future use of intersectional lineage tracing analysis approaches or single-cell RNA sequencing (scRNA-seq) of cells from early stages of coronary vascular specification might shed more light on this process (Pu et al, 2018;Su et al, 2018).…”
Section: Ra and The Development Of Coronary Vesselsmentioning
confidence: 99%
“…Other epicardial contributions toward coronary vascular development could be in the form of angiogenic molecules secreted by epicardial cells or EPDCs . APJ is specifically expressed in sinus venosus-derived coronary vessels, and APJ signalling via its alternate ligand, elabela, was required for their angiogenic sprouting (Chen et al, 2014;Sharma, Ho, et al, 2017). Several studies also implicate RA-RARα signaling in the regulation of the expression of apelin and apelin receptor (APJ) expression in human and rat endothelial cells and in vivo in hypertensive rats (Shi, Yuan, et al, 2017;Zhong et al, 2005).…”
Section: Ra and The Development Of Coronary Vesselsmentioning
confidence: 99%
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