Alternative Pathway Activation of the Complement System in Preterm Infants with Early Onset Infection

Zilow, E P; Hauck, W.; Linderkamp, Otwin; Zilow, G.

doi:10.1203/00006450-199703000-00005

Cited by 27 publications

(23 citation statements)

References 34 publications

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“…Irrespective of very low native complement protein levels, term and preterm babies can generate remarkable amounts of activation products of the complement cascade, as demonstrated during infection (Hogasen et al 2000;Zilow et al 1993Zilow et al , 1997. Hogasen et al (2000) looked at a group of premature infants (median gestation of 30 weeks) who were born with increased risk of infection after premature prolonged rupture of membranes (PPROM).…”

Section: Response Of Neonatal Complement To Bacteriamentioning

confidence: 99%

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

2012

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Section: Response Of Neonatal Complement To Bacteriamentioning

confidence: 99%

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

2012

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“…Decreased plasma concentrations of cytokines [1], complement factors [2] and mannose binding lectin [3] are examples of immature innate immunity.…”

Section: Introductionmentioning

confidence: 99%

Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection

Müller

End

Weiß

et al. 2007

Clinical and Experimental Immunology

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SummaryDeleted in Malignant Brain Tumours 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds and aggregates various bacteria and viruses in vitro. Studies in adults have shown that DMBT1 is expressed mainly by mucosal epithelia and glands, in particular within the respiratory tract, and plays a role in innate immune defence. We hypothesized that respiratory DMBT1 levels may be influenced by various developmental and clinical factors such as maturity, age and bacterial infection. DMBT1 levels were studied in 205 tracheal aspirate samples of 82 ventilated preterm and fullterm infants by enzyme-linked immunosorbent assay. Possible effects of various clinical parameters were tested by multiple regression analysis. DMBT1 levels increased significantly with lung maturity (P < 0·0001 for both gestational and postnatal age) and in small-for-gestational-age infants (P = 0·0179). An increase of respiratory DMBT1 levels was detected in neonatal infections (P < 0·0001). These results were supported by Western blotting. Immunohistochemical analyses of archived newborn lung sections (n = 17) demonstrated high concentrations of DMBT1 in lungs of neonates with bacterial infections. Our data show that preterm infants are able to up-regulate DMBT1 in infection as an unspecific immune reaction.

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“…The elevated levels of C5a have been shown to be increased in various diseases including pneumothorax, intracerebral hemorrhages, respiratory distress (Enskog et al 1996) and early onset of infection in preterm infants which may be useful for diagnosis and follow-up (Zilow et al 1997). In addition, C5a was reported to be a contributing factor leading to mesenteric ischemia/reperfusion injury (Fleming et al 2003), which is a predisposing factor in the pathogenesis of NEC (Lin et al 2008;Thompson and Bizzarro 2008;Schnabl et al 2008).…”

mentioning

confidence: 99%

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

Tayman

Tonbul

Kahveci³

et al. 2011

Tohoku J. Exp. Med.

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Necrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal emergency, predominantly affecting low-birth weight, premature infants. Early clinical signs of NEC are nonspecific and the laboratory findings are not fully reliable. Its severe morbidities and rapid progression require the application of new biomarkers for early diagnosis and intervention. The complement activation product, C5a (anaphylatoxin) has been reported to be a contributing factor leading to mesenteric ischemia/reperfusion injury which is a predisposing factor in the pathogenesis of NEC. Therefore, our aim was to evaluate the efficacy of serial C5a measurements in the diagnosis and follow-up of NEC. Preterm infants, whose gestational age and weight matched each other, were grouped as controls (n = 23) and NEC (n = 22). Serum levels of C5a, serum amyloid-A (SAA), C-reactive protein (CRP), and interleukin-6 (IL-6) levels were measured on the third day of life for the control group and on the day of diagnosis (1 st day), 3 rd and 7 th days of the NEC group. C5a, SSA, CRP, and IL-6 levels were significantly higher in the NEC patients compared to the control group (P < 0.05) in the follow-up. Additionally, serum levels of C5a were found to be more accurate than the other parameters for the prediction of death and requirement for surgery at the time of diagnosis (P < 0.05). In conclusion, C5a may be useful as a new marker for both diagnosis and follow-up of infants with NEC in combination with clinical and radiographical findings.

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Alternative Pathway Activation of the Complement System in Preterm Infants with Early Onset Infection

Cited by 27 publications

References 34 publications

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

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