Abstract:Alternative oxidases (AOX) are non‐proton‐pumping enzymes present in most groups of organisms, but naturally absent in the mitochondria of vertebrates and insects. However, its xenotopic expression in mammalian and Drosophila models have suggested an immense therapeutic potential, as diverse phenotypes related to mitochondrial diseases have been attenuated. The expression of this enzyme creates an extra pathway for oxygen reduction when the cytochrome c segment of the electron transfer system is overloaded, re… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.