Alternative medicine for allergy and asthma

Ziment, Irwin; Tashkin, Donald P.

doi:10.1067/mai.2000.109432

Cited by 115 publications

(64 citation statements)

References 54 publications

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“…Interestingly, four out of the five classes of drugs that are presently being used as an asthma treatment originate from herbs (Ziment and Tashkin, 2000). For example, green tea brewed from the leaves of the plant Camellia sinensis was found to block the expression of an anti-inflammatory cytokine (Li et al, 2007) and extracts prepared from grape seeds which have potent antioxidant and anti-inflammatory effects were shown to alleviate inflammation and asthma associated pathologies in a mouse model of ovalumin-induced asthma (Mahmoud, 2012).…”

Section: Discussionmentioning

confidence: 99%

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

McKnight¹

2014

American Journal of Immunology

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Plant based products represent a promising alternative to conventional treatments for inflammation. Moringa oleifera Lam is a tree rich in proteins, vitamins, minerals and a variety of phytochemcals with health benefits. Among the reported health benefits are antioxidant and anti-inflammatory properties. The purpose of this study was to investigate whether tea brewed from dried Moringa leaves would abrogate inflammation in a mouse model of acute lung inflammation induced by LPS or extracts prepared from dust collected from a swine confinement facility (DE). Mice were offered water or Moringa tea for seven days. Tea consumption was significantly greater than that of water consumption on days 1 and 6, but there were no significant differences in weight gain or food consumption. On day seven, mice from both groups were forced to inhale, via intranasal challenge, either Phosphate Buffered Saline (PBS), Lipopolysaccharide (LPS) [10 µg mLCompared to mice that drank water, mice that drank Moringa tea had significantly less protein (p<0.05) and cellular influx (p<0.0001) into the lung after inhalation of 10% DE. No difference in neutrophil migration into the lungs of water and M. tea groups after LPS or DE challenge was detected. But mice that drank tea had significantly (p<0.05) more neutrophils with apoptotic morphology after DE challenge. TNF-α expression 24 h after inhalation of 10% DE, was significantly higher (p<0.05) in lungs of M. tea mouse group as compared to water group. This increase in TNF-α was accompanied by higher levels of pro and anti-inflammatory cytokines. Finally, activation of c-Jun N-terminal Kinase (JNK) in lungs of M. tea+DE group 24 h post inhalation was decreased. Taken together these results suggest that Moringa oleifera leaf tea exerts antiinflammatory properties on acute lung inflammation induced by swine confinement dust through a mechanism involving neutrophil regulation and JNK activation.

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Section: Discussionmentioning

confidence: 99%

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

McKnight¹

2014

American Journal of Immunology

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“…*indicates p < 0.05. many undesirable side effects of systemic corticosteroids have been reported (Akinbami and Schoendorf, 2002). On the other hand, the application of complementary preparations for asthma, especially herbal medicine, has prevailed (Bielory and Lupoli, 1999;Li et al, 2000;Ziment and Tashkin, 2000). However, the lack of blinding, description of adverse effects and withdrawal rates are frequent limitations to demonstrating the availability of herbal medicine such as traditional Chinese medicines.…”

Section: Laboratory Testsmentioning

confidence: 98%

Clinical evaluation of the Chinese herbal medicine formula STA‐1 in the treatment of allergic asthma

Chang

Huang

Hsu

2006

Phytotherapy Research

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Although some formulae of traditional Chinese medicines (TCM) have been used for antiasthma treatment, few of them have had sufficient discussion on their efficacy, safety and mechanisms. In this study, the availability of the TCM formula STA-1 for the treatment of allergic asthma was investigated by conducting a double-blind, placebo-controlled and randomized trial. One hundred and twenty patients between the ages of 5 to 20 years with mild-to-moderate asthma were included. These patients were treated with either STA-1 or placebo in a dose of 80 g/kg/day and were administered twice daily for 6 months. The main outcome measures were a daily diary record of symptoms, supplementary bronchodilator and glucocorticoid treatment, changes of pulmonary function (forced expiratory volume in 1 s), changes of total and Dermatophagoides pteronyssinus (DP)-specific IgE and side effects. The results showed a statistically significant reduction of symptom scores, systemic steroid dose, total IgE and specific IgE in the STA-1 group. Furthermore, STA-1 also improved the pulmonary lung function FEV(1) compared with the placebo group and only minimal side effects were shown. These results suggested that STA-1 is available for the treatment of mild-to-moderate chronic asthma.

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“…However, there have been concerns in the past that the use of clove cigarettes may induce the development of the adult respiratory distress syndrome (ARDS) in susceptible subjects. It is of interest that it was recently shown that clove oil enhances the surfactant effects of phospholipids; 4 eucalyptus (or cineole, its main constituent) may have 5 The smoke of marijuana can reduce bronchospasm in asthma, 6 but continued use may lead to an increase in coughing since it can induce bronchitis. The effects of oral marijuana and its synthetic derivatives are not so dramatic in asthma; they have not been evaluated as specific therapy for cough, but the sedative and antiemetic effects of marijuana products suggests that suitable derivatives could reduce non-specific coughing.…”

Section: Peripherally Acting Antitussivesmentioning

confidence: 99%

“…Bioflavonoids, found in many herbs, may act as antiallergens; the best known of these agents are quercetin and kaempferol. 1 Traditional Japanese Kampo medicines (each of which contain ten or more herbs) have been shown to have anti-inflammatory effects, including anti-leukotriene properties, 6,18,19 Licorice also has anti-inflammatory, cortisone-like properties. 1 Cromolyn is derived from the herb Ammi visnaga, which is a traditional agent for asthma and cough.…”

Section: Herbal Chemicalsmentioning

confidence: 99%

Herbal Antitussives

Ziment¹

2002

Pulmonary Pharmacology & Therapeutics

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The mechanisms of actions of cough medicines are not always known. The problem is exacerbated for herbal medicines, where the effectiveness of the plant or its phytochemicals have rarely been carefully evaluated. Moreover, the most active phytomedicinal constituent is difficult to identify, and the expense and difficulty of such studies discourages sponsors who may not be able to benefit by subsequent exclusive marketing of the herbal remedy. Most popular herbs used as cough medicines appear to be demulcents whose action is confined to the oropharynx. It is probable that the vast majority of allegedly effective herbal cough medicines act as non-specific emetic-expectorants. The proof of activity of even marketed herbal derivatives such as guaifenesin and codeine is difficult to obtain. It is therefore likely that herbal cough medications will never be shown to be more active than placebos. Nevertheless, these plant products will continue to be popular remedies for patients and their health care advisors.

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Alternative medicine for allergy and asthma

Cited by 115 publications

References 54 publications

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

Clinical evaluation of the Chinese herbal medicine formula STA‐1 in the treatment of allergic asthma

Herbal Antitussives

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