The bias in Monte Carlo calculations of the neutron-physical characteristics of full-scale models of reactors and storage sites for nuclear fuel is investigated. The bias is shown to arise directly from the nature of the Monte Carlo solution of the eigenvalue problem and estimates of similar bias without loss of generality are proposed.As computers become more powerful, the Monte Carlo method is used more and more for calculating full-scale models of storage sites for spent nuclear fuel and of nuclear-reactor cores. This is increasing interest in understanding the specific features of the Monte Carlo solution of the homogeneous stationary neutron-transport equation.In Monte Carlo modeling, the solution and all its linear functionals are determined to within a factor, and therefore ratios of the functionals, i.e., linear-fractional functionals, are meaningful. When such functionals are calculated, biases arise in their estimates and not their values.The questions studied in the present paper have been attracting the attention of many specialists (see, for example, [1-7]). A set of model problems has been developed to check the proposed algorithms (for example, [8]).The most important result in this field is an asymptotic formula for determining the bias of the estimate of k eff , which is valid for large values of the number of neutrons in a generation. The formula makes it possible to estimate efficiently the systematic error in k eff in practical calculations, though it has been derived only for a method of simulation with a constant number of neutrons in a generation, a finite-dimensional model of a reactor, and the simplest analog estimate of k eff from the number of neutrons produced in the fissioning of a nucleus.The question of whether or not the systematic errors in the reaction rates calculated by the methods of generations can be estimated and the range of application of the formulas for the bias of the estimates of k eff can be expanded has thus far remained open. In the present paper, without loss of generality, general and asymptotic formulas for determining the bias of any estimates of any reaction rates calculated by simulation according to generations are obtained for real neutron-multiplication systems. It is important that all proposed proofs are technically simple and give a clear picture of the mechanism leading to the appearance of biases and the possibilities for estimating them.Formulation of the Problem. The problem is to calculate by the method of generations the main intrinsic value of k eff and the normalized reaction rates of neutrons, determined for the main eigenfunction Ψ(x) of the equation for the generation density of fission neutrons in a conditionally critical reactor. This equation can be written in operator form as follows:(1)