Alternative forms of rat TrkC with different functional capabilities

Valenzuela, David M.; Maisonpierre, Peter C.; Glass, David J.; Rojas, Eduardo; Nuñez, Lorna; Yuan, Kong; Gies, David R.; Stitt, Trevor N.; Ip, Nancy Y.; Yancopouloš, George D.

doi:10.1016/0896-6273(93)90211-9

Cited by 360 publications

(276 citation statements)

References 38 publications

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“…In addition, incubation of slices of visual cortex from developing ferrets in NGF-containing medium for 36 h resulted in changes in dendritic morphology of cortical neurons (McAllister et al, 1995). There have been some reports of trkA mRNA expression in cortex using in situ hybridization (Miranda et al, 1993), northern blots (Valenzuela et al, 1993), and polymerase chain reaction, PCR (Cellerino and Ma¡ei, 1996). However, other studies have not replicated these results (Holtzman et al, 1992;Merlio et al, 1992;Ringstedt et al, 1993).…”

Section: Possible Actions Of Ngf On Cortical Neuronsmentioning

confidence: 99%

Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development

Silver¹,

Fagiolini²,

Gillespie³

et al. 2001

Neuroscience

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AbstractöIntracerebroventricular or intracortical administration of nerve growth factor (NGF) has been shown to block or attenuate visual cortical plasticity in the rat. In cats and ferrets, the e¡ects of exogenous NGF on development and plasticity of visual cortex have been reported to be small or nonexistent. To determine whether locally delivered NGF a¡ects ocular dominance column formation or the plasticity produced by monocular deprivation in cats at the height of the critical period, we infused recombinant human NGF into the primary visual cortex of kittens using an implanted cannula minipump. NGF had no e¡ect on the normal developmental segregation of geniculocortical a¡erents into ocular dominance columns as determined both physiologically and anatomically. The plasticity of binocular visual cortical responses induced by monocular deprivation was also normal in regions of immunohistochemically detectable NGF infusion, as measured using intrinsic signal optical imaging and single-unit electrophysiology. Immunohistochemical analysis of the basal forebrain regions of the same animals demonstrated that the NGF infused into cortex was biologically active, producing an increase in the number of NGF-, TrkA-, p75 NTR -, and choline acetyltransferase-positive neurons in basal forebrain nuclei in the hemisphere ipsilateral to the NGF minipump compared to the contralateral basal forebrain neurons.We conclude that NGF delivered locally to axon terminals of cholinergic basal forebrain neurons resulted in increases in protein expression at the cell body through retrograde signaling. ß 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.Key words: TrkA, p75, choline acetyltransferase, retrograde transport, acetylcholine, monocular deprivation.Monocular deprivation (MD) is a well-studied model of experience-dependent cortical plasticity. When one eye of an animal is occluded during a critical period of development, that eye loses most of its ability to drive neurons in primary visual cortex, shifting the distribution of visual responses to favor the nondeprived eye (Wiesel and Hubel, 1963). Intracerebroventricular (ICV) administration of the neurotrophin nerve growth factor (NGF) to rats during a critical period of development blocks the e¡ects of MD (Domenici et al., 1991;Ma¡ei et al., 1992). This has been demonstrated at several levels of analysis, including physiological, anatomical, immunocytochemical, and behavioral (for a review, see Cellerino and Ma¡ei, 1996). Infusion of NGF directly into developing rat visual cortex also prevents physiological ocular dominance plasticity (Lodovichi et al., 2000).In addition, anti-NGF antibodies prevent normal anatomical and physiological development of the visual system when they are administered to rats by implantation of antibody-secreting hybridoma cells in the lateral ventricle (Berardi et al., 1994). These antibodies also prolong the critical period for ocular dominance plasticity in the rat (Domenici et al., 1994a). Together, these results demonstrate an imp...

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Section: Possible Actions Of Ngf On Cortical Neuronsmentioning

confidence: 99%

Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development

Silver¹,

Fagiolini²,

Gillespie³

et al. 2001

Neuroscience

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show abstract

“…The full length isoform contains a tyrosine kinse domain. In addition there are truncated isoforms without tryosine kinase activity and isoforms with amino acid inserts in the kinase domain (Tsoulfas et al, 1993;Valenzuela et al, 1993;Garner and Large, 1994).…”

Section: Introductionmentioning

confidence: 99%

Neurotrophin‐3 signaling in mammalian Merkel cell development

Szeder

Grim

Kučera

et al. 2003

Developmental Dynamics

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“…This is particularly useful in organisms with a limited genome size. In neurones, alternative splicing regulates the functions of many gene products such as Oct-2 transcription factor, agrin, GABA A-receptor, NMDA receptor, and trk genes (Barbacid 1994;Kofuji et al 1991;Lillycrop & Latchman 1992;Valenzuela et al 1993;Bowe & Fallon 1995;Traynelis et al 1995;Ehlers et al 1996). Alternatively spliced exons encode distinct functional domains that play crucial roles in neuronal functions, and thereby exert important effects on cell function.…”

Section: Introductionmentioning

confidence: 99%