Alternative effective modality of Leipzig applicator with an electron beam for the treatment of superficial malignancies

Hwang, Ing-Ming; Lin, Shen-Yeh; Lin, Li‐Ching; Ding, Hueisch‐Jy

doi:10.1016/s0168-9002(03)01664-4

Cited by 17 publications

(9 citation statements)

References 20 publications

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“…In fact, during HDR-BT, the dose remains on the surface and does not penetrate deeply with optimal sparing of normal tissues due to dose concentration into the clinical target volumes (CTV) and rapid dose fall-off at target periphery [10, 11, 12, 13, 14, 15, 16, 17]. Published studies have mainly reported standard fractionation and hypofractionated brachytherapy regimens in patients treated with HDR-BT, and the biological effective dose (BED) was often calculated due to define the total dose and dose for fractions regimen for a better local control and acceptable late and acute toxicity [19, 20, 21, 22, 23, 24, 25, 26, 33, 34, 35, 36, 37].…”

Section: Resultsmentioning

confidence: 99%

“…Compared to the other radiotherapy technique, HDR-BT might be a better therapeutic option due to essential advantages such as high radiation dose concentration into the clinical target volumes (CTV), rapid dose fall-off at target periphery, optimal sparing of normal tissues in sensitive structures, shorter treatment time, and the use of hypofractionated course [11, 12, 13, 14, 15, 16, 17]. …”

Section: Purposementioning

confidence: 99%

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Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature

Delishaj¹,

Rembielak²,

Manfredi³

et al. 2016

jcb

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PurposeThe incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence. Radiotherapy is an effective alternative of surgery, and brachytherapy (BT) might be a better therapeutic option due to high radiation dose concentration to the tumor with rapid dose fall-off resulting in normal tissues sparing. The aim of this review was to evaluate the local control, toxicity, and cosmetic outcomes in NMSC treated with high-dose-rate BT (HDR-BT).Material and methodsIn May 2016, a systematic search of bibliographic database of PubMed, Web of Science, Scopus, and Cochrane Library with a combination of key words of “skin cancer”, “high dose rate brachytherapy”, “squamous cell carcinoma”, “basal cell carcinoma”, and “non melanoma skin cancer“ was performed. In this systematic review, we included randomized trials, non-randomized trials, prospective and retrospective studies in patients affected by NMSC treated with HDR-BT.ResultsOur searches generated a total of 85 results, and through a process of screening, 10 publications were selected for the review. Brachytherapy was well tolerated with acceptable toxicity and high local control rates (median: 97%). Cosmetic outcome was reported in seven study and consisted in an excellent and good cosmetic results in 94.8% of cases.ConclusionsBased on the review data, we can conclude that the treatment of NMSC with HDR-BT is effective with excellent and good cosmetics results, even in elderly patients. The hypofractionated course appears effective with very good local disease control. More data with large-scale randomized controlled trials are needed to assess the efficacy and safety of brachytherapy.

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Section: Resultsmentioning

confidence: 99%

Section: Purposementioning

confidence: 99%

Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature

Delishaj¹,

Rembielak²,

Manfredi³

et al. 2016

jcb

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“…The applicators are cup-shaped and tungsten shielded to limit the dose to the irradiation area and they are intended to treat surface lesions utilizing a contact treatment technique. The VLCAPP were designed on the base of the Leipzig applicators [1][2][3][4], from the same vendor, in order to overcome the principal dosimetric problems that these applicators exhibit, a very heterogeneous dose distribution in planes parallel to the skin surface. The dose distribution shows a significant penumbra reducing the useful irradiation field size of the applicators and the prescription at a depth on axis would not guarantee that the entire layer receives the intended dose.…”

Section: Purposementioning

confidence: 99%

Dosimetric evaluation of internal shielding in a high-dose-rate skin applicator

et al. 2009

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“…The hypofractionation afforded by the superficial deposition of dose using this methodology has allowed delivery of radiation using fewer fractions with good cosmetic results. (8)(9)(10)(11)(12). The primary challenge facing the field of skin surface brachytherapy is absence of prospective trials and clinical guidelines.…”

Section: Introductionmentioning

confidence: 99%

Skin Surface Brachytherapy: A Survey of Contemporary Practice Patterns

2016

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Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptPurpose-The aim of this study was to define current patterns of care among radiation oncologists who utilize skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings.Methods and materials-A 30 question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy.

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Alternative effective modality of Leipzig applicator with an electron beam for the treatment of superficial malignancies

Cited by 17 publications

References 20 publications

Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature

Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature

Dosimetric evaluation of internal shielding in a high-dose-rate skin applicator

Skin Surface Brachytherapy: A Survey of Contemporary Practice Patterns

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