Alternative Blood Products and Clinical Needs in Transfusion Medicine

Whitsett, Carolyn; Vaglio, Stefania; Grazzini, Giuliano

doi:10.1155/2012/639561

Cited by 6 publications

(6 citation statements)

References 143 publications

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“…In Beijing, the transfusion volume has increased from 53.6 million milliliters in 1998 to 140 million milliliters in 2008, a 161% increase in 10 years . Beijing's transfusion rate was 57 units/1000 population, higher than that of Canada (32/1000), the European Union (40/1000 on average), and the United States (49/1000) 12‐14. In Nanjing, transfusion volume was 20 million milliliters in 2011, accounting for only 76% of its clinical demand for blood .…”

Section: Blood Supply In Chinamentioning

confidence: 99%

“…11 Beijing's transfusion rate was 57 units/1000 population, higher than that of Canada (32/1000), the European Union (40/1000 on average), and the United States (49/1000). [12][13][14] In Nanjing, transfusion volume was 20 million milliliters in 2011, accounting for only 76% of its clinical demand for blood. 15 Other large cities like Kunming, Urumqi, and Qingdao have also reported a significant unmet need for blood.…”

Section: Increasing Clinical Demand and Shortage Of Supplymentioning

confidence: 99%

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Blood safety and availability: continuing challenges in China's blood banking system

et al. 2013

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Social and economic development, along with increased health care coverage, has caused a sharp increase in the clinical demand for blood in China. Whole blood collection has increased rapidly in the past decade but has failed to keep pace with the ever-increasing demand. Overall, the country's blood safety has been improved with 99% of whole blood donations collected from voluntary unpaid donors. However, the unmet clinical demand for blood and the increasing incidence of human immunodeficiency virus and syphilis in the general population pose new challenges to China's blood banking system. To ensure a safe and adequate blood supply, continued efforts are required to recruit and retain a sufficient number of low-risk voluntary blood donors, improve donor prescreening and blood testing process, ease donor restrictions, and strengthen patient blood management.

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Section: Blood Supply In Chinamentioning

confidence: 99%

Section: Increasing Clinical Demand and Shortage Of Supplymentioning

confidence: 99%

Blood safety and availability: continuing challenges in China's blood banking system

et al. 2013

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“…However, collected blood sometimes associated with a risk of infectious pathogen transmission (Hoofnagle 1990;Schreiber et al 1996;Whitsett et al 2012). Transmission of hepatitis B virus (HBV) infection through donated blood is more common than hepatitis C virus (HCV) infection (1:60000 versus 1:103000) (Schreiber et al 1996;Chen and Morgan 2006;Lok and McMahon 2009).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Vaccine Reduced the Prevalence of Antibodies to Hepatitis B Core Antigen in Blood Donors in Aseer Region,Saudi Arabia

Ibrahim

Dajem

Heijan³

et al. 2014

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Viral hepatitis is one of the major problem worldwide. The detection of hepatitis B virus (HBV) surface antigen (HBsAg), antibodies to HBV core antigen (HBc-Ab), and HBV-DNA in donated blood in Aseer Region (Southern part of Kingdom of Saudi Arabia) to detect prevention of the residual risk of transfusion transmitted HBV, donors in window period of HBV infection and the prevalence of HBV infection was attempted. The study was conducted on random blood samples collected from healthy blood donor volunteers, who were referred to blood transfusion centers found at Aseer region, during the period from March 2012 to January 2013. All the collected blood units were screened for hepatitis B surface antigen (HBsAg), anti-HBc, hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, human T-cell lymphotropic virus (HTLV) I/II, venereal disease research laboratory (VDRL), and malaria. All donated blood samples were checked for HBV-DNA, HCV-RNA, and HIV-RNA by nucleic acid test (NAT) technology. Of 6698 (19 females (0.28%) and 6679 males (99.72)) blood donors screened, with median age of 28 (female) and 30 years (males), 69 (1.03%) were HBsAg positive of them 64 (0.96) were positive to HBV-DNA, 411 (6.14%) were anti-HBc positive of them 73 (1.09%) were positive to HBV-DNA. Cases positive to both HBsAg and HBc-Ab were 68 (1.02%) of them 63 (0.94%) were positive to HBV-DNA. All HBsAg and HBc-Ab positive cases were shown to be among male volunteers. In conclusion, prevalence of HBsAg in Asser region is very low. The rate of HBc-Ab in units of blood donation is relatively high. The presence of HBV-DNA in HBc-Ab positive donations makes it risky for use. Vaccination program against HBV decreased the rate of HBV transmission.

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“…The clinical demand for blood transfusion remains high in surgical interventions and hematologic malignancies. However, the imbalance in blood supply and demand has been intensified due to demographic aging, increasing outbreaks in the transmission of infectious diseases such as Ebola and dengue, and limited compatibility of donor blood [1, 2]. The aging of the population reduces the number of healthy donors and increases the incidence of diseases that require transfusion [3].…”

Section: Introductionmentioning

confidence: 99%

Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources

Seo

Shin

Kim

et al. 2019

Stem Cells International

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Blood transfusions hold an indispensable part in the modern healthcare system. Up to date, the blood supply is largely dependent on donations. Unfortunately, collecting the clinical-grade blood products has become a challenging mission due to accelerated population aging, which not only increases the need for blood transfusions but also decreases the number of healthy donors. Moreover, individuals with severe hematological abnormalities or rare blood phenotypes need alternative therapeutic approaches instead of conventional blood transfusion. In these aspects, the concept ofin vitro/ex vivoproduction of blood cells has been emerging and many attempts have been focused on manufacturing mature erythrocytes, so-called red blood cells (RBCs), the most common and important component among the blood derivatives. In this review, we provide a general overview regarding the current strategies for generating RBCs from various stem cell sources including pluripotent stem cells (PSCs) as well as circulating blood stem cells and the remaining challenges that must be overcome prior to their practical application.

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Alternative Blood Products and Clinical Needs in Transfusion Medicine

Cited by 6 publications

References 143 publications

Blood safety and availability: continuing challenges in China's blood banking system

Blood safety and availability: continuing challenges in China's blood banking system

Hepatitis B Vaccine Reduced the Prevalence of Antibodies to Hepatitis B Core Antigen in Blood Donors in Aseer Region,Saudi Arabia

Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources

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