Alternative Anti-Infective Treatments to Traditional Antibiotherapy against Staphylococcal Veterinary Pathogens

Mourenza, Álvaro; Gil, José A.; Mateos, Luís M.; Letek, Michal

doi:10.3390/antibiotics9100702

Cited by 6 publications

(5 citation statements)

References 107 publications

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“…There is also great interest in proteins and peptides with bactericidal activity synthesized by bacteria, plants, invertebrates, vertebrates and mammals. This solution is based on the use of antimicrobial peptides produced by generally recognized as safe (GRAS) bacteria like Lactobacillus spp., Streptomyces , Micrococcus or yeast Saccharomyces and Candidia [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance in Bacteria—A Review

et al. 2022

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Background: A global problem of multi-drug resistance (MDR) among bacteria is the cause of hundreds of thousands of deaths every year. In response to the significant increase of MDR bacteria, legislative measures have widely been taken to limit or eliminate the use of antibiotics, including in the form of feed additives for livestock, but also in metaphylaxis and its treatment, which was the subject of EU Regulation in 2019/6. Numerous studies have documented that bacteria use both phenotypis and gentic strategies enabling a natural defence against antibiotics and the induction of mechanisms in increasing resistance to the used antibacterial chemicals. The mechanisms presented in this review developed by the bacteria have a significant impact on reducing the ability to combat bacterial infections in humans and animals. Moreover, the high prevalence of multi-resistant strains in the environment and the ease of transmission of drug-resistance genes between the different bacterial species including commensal flora and pathogenic like foodborne pathoges (E. coli, Campylobacter spp., Enterococcus spp., Salmonella spp., Listeria spp., Staphylococcus spp.) favor the rapid spread of multi-resistance among bacteria in humans and animals. Given the global threat posed by the widespread phenomenon of multi-drug resistance among bacteria which are dangerous for humans and animals, the subject of this study is the presentation of the mechanisms of resistance in most frequent bacteria called as “foodborne pathoges” isolated from human and animals. In order to present the significance of the global problem related to multi-drug resistance among selected pathogens, especially those danger to humans, the publication also presents statistical data on the percentage range of occurrence of drug resistance among selected bacteria in various regions of the world. In addition to the phenotypic characteristics of pathogen resistance, this review also presents detailed information on the detection of drug resistance genes for specific groups of antibiotics. It should be emphasized that the manuscript also presents the results of own research i.e., Campylobacter spp., E. coli or Enetrococcus spp. This subject and the presentation of data on the risks of drug resistance among bacteria will contribute to initiating research in implementing the prevention of drug resistance and the development of alternatives for antimicrobials methods of controlling bacteria.

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Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance in Bacteria—A Review

et al. 2022

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“…It is unknown whether the filamentous nature of Herpetosiphon enables it to move across the SCC surface; however, it could reside within an SCC biofilm, along with several other biofilm-forming bacteria detected within the lesions of Staphylococcus , Janibacter , and Filifactor ( 64 – 67 ). This genus also produces secondary metabolites that contain antimicrobial compounds that could be further examined for utilization as a topical microbiome-based therapy ( 62 , 68 ). No correlation was observed between Janibacter and Herpetosiphon and the staphylococcal species in the samples from the present study (Fig.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs

Bromfield,

Zaugg,

Straw

et al. 2024

mSphere

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Human cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) display microbial dysbiosis with an enrichment of staphylococcal species, which have been implicated in AK and SCC progression. SCCs are common in both felines and canines and are often diagnosed at late stages leading to high disease morbidity and mortality rates. Although recent studies support the involvement of the skin microbiome in AK and SCC progression in humans, there is no knowledge of this in companion animals. Here, we provide microbiome data for SCC in cats and dogs using culture-independent molecular profiling and show a significant decrease in microbial alpha diversity on SCC lesions compared to normal skin ( P ≤ 0.05). Similar to human skin cancer, SCC samples had an elevated abundance of staphylococci relative to normal skin—50% (6/12) had >50% staphylococci, as did 16% (4/25) of perilesional samples. Analysis of Staphylococcus at the species level revealed an enrichment of the pathogenic species Staphylococcus felis in cat SCC samples, a higher prevalence of Staphylococcus pseudintermedius in dogs, and a higher abundance of Staphylococcus aureus compared to normal skin in both companion animals. Additionally, a comparison of previously published human SCC and perilesional samples against the present pet samples revealed that Staphylococcus was the most prevalent genera across human and companion animals for both sample types. Similarities between the microbial profile of human and cat/dog SCC lesions should facilitate future skin cancer research. IMPORTANCE The progression of precancerous actinic keratosis lesions (AK) to cutaneous squamous cell carcinoma (SCC) is poorly understood in humans and companion animals, despite causing a significant burden of disease. Recent studies have revealed that the microbiota may play a significant role in disease progression. Staphylococcus aureus has been found in high abundance on AK and SCC lesions, where it secretes DNA-damaging toxins, which could potentiate tumorigenesis. Currently, a suitable animal model to investigate this relationship is lacking. Thus, we examined the microbiome of cutaneous SCC in pets, revealing similarities to humans, with increased staphylococci and reduced commensals on SCC lesions and peri-lesional skin compared to normal skin. Two genera that were in abundance in SCC samples have also been found in human oral SCC lesions. These findings suggest the potential suitability of pets as a model for studying microbiome-related skin cancer progression.

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“…Such studies show that the effect of antibiotics, whether as growth promoters or as prophylactic elements, is minimal and almost irrelevant in an environment where hygienic-sanitary conditions are ideal (F. Aarestrup, 2012;Close, 2000;Noschang et al, 2017;Ollé et al, 2017). In addition to the health conditions in which pigs must be housed, these studies show alternatives to antibiotic growth promoter that demonstrate satisfactory efficacy (F. Aarestrup, 2012;Brown et al, 2017;Close, 2000;Marquardt & Li, 2018;Mourenza et al, 2020;Thacker, 2013).…”

Section: Use Of Antibiotics In Pig Farmingmentioning

confidence: 99%

“…Therefore, studies aimed at finding alternatives to these growth promoters are being increasingly carried out, showing the promising use of substances such as probiotics and prebiotics, clay minerals, egg yolk antibodies, essential oils, isolated fatty acids, and phytobiotics (F. Aarestrup, 2012;Brown et al, 2017;Close, 2000;Gheisar & Kim, 2018;Liao & Nyachoti, 2017;Liu et al, 2018;Marquardt & Li, 2018;Mourenza et al, 2020;Thacker, 2013). Although there is a great deal of research involving alternatives to the use of antibiotics in several areas, it should focus on using them correctly, especially with regard to the mechanisms of acquired or intrinsic resistance in bacteria (Willing et al, 2018).…”

Section: Use Of Antibiotics In Pig Farmingmentioning

confidence: 99%

Presence of antibiotic-resistant bacteria in pigs for consumption - one health challenge - Literature review

Santos

Barbosa

Martins³

et al. 2023

Sem. Ci. Agr.

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Pig farming is an area of livestock that has been developing the most in Brazil and the world, with production increasing every year, generating jobs, and being of great importance for the Brazilian economy. In swine production, great health enables these animals to reach their highest point of development and antimicrobials are used, either prophylactically or through food, as growth promoters. Within swine culture, there is a concern regarding antibiotic-resistant bacteria; however, Staphylococcus spp. do not receive the necessary prominence in research, since the pathologies caused by them do not tend to cause great economic losses. Therefore, this review aimed to highlight the importance of bacterial resistance within breeding stock, its possible origins, the importance of Staphylococcus spp. within this topic, and its evolution in swine farming over the years. For this, studies were selected, with an emphasis on information such as country, number of samples, presence of Staphylococcus spp. resistant to methicillin, breeding phase, and phenotypic and molecular tests. In addition, publications were selected that show the importance of understanding the biological and resistance profiles of Staphylococcus spp. in swine herds in Brazil and around the world.

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Alternative Anti-Infective Treatments to Traditional Antibiotherapy against Staphylococcal Veterinary Pathogens

Cited by 6 publications

References 107 publications

Antibiotic Resistance in Bacteria—A Review

Antibiotic Resistance in Bacteria—A Review

Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs

Presence of antibiotic-resistant bacteria in pigs for consumption - one health challenge - Literature review

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