Alternative and efficient one-pot three-component synthesis of substituted 2-aryl-4-styrylquinazolines/4-styrylquinazolines from synthetically available 1-(2-aminophenyl)-3-arylprop-2-en-1-ones: characterization and evaluation of their antiproliferative activities

Abstract

The AcONH4-promoted and catalyst-free one-pot three-component synthesis of diverse substituted 4-styrylquinazolines have been developed from 2′-aminochalcones, aromatic aldehydes/trimethyl orthoformate, and ammonium acetate.