“…Alternative polyadenylation plays an essential role in dendritic and axonal localization of many transcripts (Shigeoka et al, 2016; Taliaferro et al, 2016; Andreassi et al, 2017; Tushev et al, 2018), including BDNF (An et al, 2008; Will et al, 2013; Vicario et al, 2015), Impa1 (Andreassi et al, 2010, 2017), importin β1 (Perry et al, 2012), mTOR (Terenzio et al, 2018), and Shank (Bockers et al, 2004; Epstein et al, 2014). Localization signals present in isoforms within the 3′UTR usually mediate the transport and activate local translation in response to extrinsic stimuli, such as neurotrophins, synaptic activation and during regeneration after injury.…”