Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

Heuer, Josef G.; Bartheld, Christopher S. von; Kinoshita, Yoshito; Evers, P.; Bothwell, Mark

doi:10.1016/0896-6273(90)90165-c

Cited by 201 publications

(90 citation statements)

References 51 publications

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“…During embryonic development, a linkage between FGFR expression and differentiation process involving phenotype transition may also occur. In accord with this concept, it has been observed that distinct FGFR are expressed at specific stages in cells expressing epithelial or mesenchymal phenotypes in the same organ (Heuer et al, 1990;Reid et al, 1990;Wanaka et al, 1990;Peters et al, 1992;Patstone et al, 1993 receptors on differentiating neural cells (Heuer et al, 1990). Accordingly, bFGF was found to enhance the promoter activity of the NGF receptor gene in neuroblastoma cells (Taiji et al, 1992).…”

Section: Modulation Of Dna Synthesis In Fgfr-transfected Cellsmentioning

confidence: 57%

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

Vallés

Jouanneau

Yamada

et al. 1994

MBoC

120

102

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We described previously that acidic fibroblast growth factor (aFGF), but not basic fibroblast growth factor (bFGF), can induce the rat carcinoma cell line NBT-II to undergo a rapid and reversible transition from epithelial to mesenchymal phenotype (EMT). We now find that NBT-II EMT is stimulated by keratinocyte growth factor (KGF) in cells grown at low density. Accordingly, a high-affinity receptor showing 98% homology to mouse FGF receptor 2b/KGF receptor was cloned and sequenced from NBT-II cells. Northern analysis indicated that mRNA for FGF receptor 2b/KGF receptor was drastically down-regulated within 1 wk in aFGF-induced mesenchymal NBT-II cells. This decrease coincided with an up-regulation of FGF receptor 2c/Bek, a KGF-insensitive, alternatively spliced form of FGF receptor 2b/KGF receptor. Functional studies confirmed that KGF could not maintain EMT induction on mesenchymal NBT-II cells. FGF receptor 1 and FGF receptor 2c/Bek could also support EMT induction when transfected into NBT-II cells in response to aFGF or bFGF. Such transfected cells could bind bFGF as well as aFGF. Therefore, EMT can be induced through different FGF receptors, but EMT may also regulate FGF receptor expression itself.

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Section: Modulation Of Dna Synthesis In Fgfr-transfected Cellsmentioning

confidence: 57%

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

Vallés

Jouanneau

Yamada

et al. 1994

MBoC

120

102

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“…Several growth factor receptors, such as FGF receptors or IGF-I receptor, which stimulates the proliferation and inhibits the apoptosis in neurons, are restricted to the proliferative zones of the developing brain (Heuer et al, 1990;Peters et al, 1993;Bartlett et al, 1992) suggesting that they may act as mitogens and/or di¡erentiation-inducing agents during neurogenesis and gliogenesis. This is particularly the case for bFGF which was recognized as one of the major neural stem cell mitogens (Ciccolini and Svendsen, 1998).…”

Section: Discussionmentioning

confidence: 99%

The SH2 domain-containing 5-phosphatase SHIP2 is expressed in the germinal layers of embryo and adult mouse brain: increased expression in N-CAM-deficient mice

et al. 2001

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AbstractöThe germinative ventricular zone of embryonic brain contains neural lineage progenitor cells that give rise to neurons, astrocytes and oligodendrocytes. The ability to generate neurons persists at adulthood in restricted brain areas. During development, many growth factors exert their e¡ects by interacting with tyrosine kinase receptors and activate the phosphatidylinositol 3-kinase and the Ras/MAP kinase pathways. By its ability to modulate these pathways, the recently identi¢ed Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2, SHIP2, has the potential to regulate neuronal development. Using in situ hybridization technique with multiple synthetic oligonucleotides, we demonstrated that SHIP2 mRNA was highly expressed in the ventricular zone at early embryonic stages and subventricular zones at latter stages of brain and spinal cord and in the sympathetic chain. No signi¢cant expression was seen in di¡erentiated ¢elds. This restricted expression was maintained from embryonic day 11.5 to birth. In the periphery, large expression was detected in muscle and kidney and moderate expression in thyroid, pituitary gland, digestive system and bone. In the adult brain, SHIP2 was mainly restricted in structures containing neural stem cells such as the anterior subventricular zone, the rostral migratory stream and the olfactory tubercle. SHIP2 was also detected in the choroid plexuses and the granular layer of the cerebellum. The speci¢city of SHIP2 expression in neural stem cells was further demonstrated by (i) the dramatic increase in SHIP2 mRNA signal in neural cell adhesion molecule (N-CAM)-de¢cient mice, which present an accumulation of progenitor cells in the anterior subventricular zone and the rostral migratory stream, (ii) the abundant expression of 160-kDa SHIP2 by western blotting in proliferating neurospheres in culture and its downregulation in non-proliferating di¡erentiated neurospheres.In conclusion, the close correlation between the pattern of SHIP2 expression in the brain and the proliferative and early di¡erentiative events suggests that the phosphatase SHIP2 may have important roles in neural development. ß

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“…In the chick system, a model for FGF function in speci®cation and patterning of the midbrain was proposed (Shamin et al, 1999). Regarding FGF receptors (FGFRs), the FGFR1 and FGFR2 genes, which were high a nity receptors for FGF-2 and HST/ 1/FGF-4, were expressed in the rat brain during postnatal development (el-Husseini et al, 1994) and developing chicken nervous system (Heuer et al, 1990). These reports suggest that the FGF family and their receptors play an important role in the CNS.…”

Section: Discussionmentioning

confidence: 99%

Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice

Yamamoto¹,

Ochiya²,

Takahama

et al. 2000

Oncogene

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Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

Cited by 201 publications

References 51 publications

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

The SH2 domain-containing 5-phosphatase SHIP2 is expressed in the germinal layers of embryo and adult mouse brain: increased expression in N-CAM-deficient mice

Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice

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