Alternating Combination Chemotherapy and Radiotherapy in Locoregionally Advanced Head and Neck Cancer

Abstract

Background: Alternating chemotherapy and radiotherapy is a minor variation of concurrent chemoradiation. This schedule has been tested in advanced head and neck cancer and has shown superiority over standard radiation in some randomized trials with only marginaly greater toxicity. In this study the efficacy and toxicity of alternating chemotherapy and radiotherapy in advanced head and neck cancer was evaluated.