Alternate receptor usage of neuropilin-1 and glucose transporter protein 1 by the human T cell leukemia virus type 1

Qi, Jin; Alkhatib, Bashar; Cornetta, Kenneth; Alkhatib, Ghalib

doi:10.1016/j.virol.2009.10.015

Cited by 22 publications

(23 citation statements)

References 39 publications

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“…This hypothesis was confirmed in a recent study [3]. NRP-1 is a 130 kDa single membrane spanning glycoprotein which acts as the co-receptor for Semaphorin 3a and VEGFA 165 .…”

Section: Not One But Three Receptor Molecules: Glut1 Hspg and Nrp-1supporting

confidence: 66%

Current concepts regarding the HTLV-1 receptor complex

et al. 2010

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The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.

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“…This hypothesis was confirmed in a recent study [3]. NRP-1 is a 130 kDa single membrane spanning glycoprotein which acts as the co-receptor for Semaphorin 3a and VEGFA 165 .…”

Section: Not One But Three Receptor Molecules: Glut1 Hspg and Nrp-1supporting

confidence: 66%

Current concepts regarding the HTLV-1 receptor complex

et al. 2010

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“…A previous study has shown that the in vitro infection of human astrocytes with HTLV-1 results in the release of proinflammatory cytokines (9). Furthermore, it has been found that neuropilin-1 and glucose transporter protein 1 are involved in HTLV-1 infection of U87 astroglioma cells and human primary astrocytes (10). Overall, these available data suggest that HTLV-1-infected astrocytes might be involved in the progression of HAM/TSP.…”

mentioning

confidence: 74%

Human T-Cell Leukemia Virus Type 1 Tax-Deregulated Autophagy Pathway and c-FLIP Expression Contribute to Resistance against Death Receptor-Mediated Apoptosis

Wang

Zhou

Shi

et al. 2014

J Virol

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The human T-cell leukemia virus type 1 (HTLV-1) Tax protein is considered to play a central role in the process that leads to adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 Tax IMPORTANCEOur study reveals that Tax-deregulated autophagy is a protective mechanism for DR-mediated apoptosis. The molecular mechanism of Tax-induced autophagy is also illuminated, which is different from Tax-increased c-FLIP. Tax can be degraded via manipulation of autophagy and TRAIL-induced apoptosis. These results outline a complex regulatory network between and among apoptosis, autophagy, and Tax and also present evidence that autophagy represents a new possible target for therapeutic intervention for the HTVL-1 related diseases.

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“…Such cooperation was also recently functionally demonstrated by data showing that inhibition of HTLV-1 entry into primary astrocytes required the blocking of the interactions with both NRP-1 and GLUT1 [14]. …”

Section: The Host Cell Actors: the Htlv-1 Receptorsmentioning

confidence: 80%

Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

Jones

Lambert

Bouttier

et al. 2011

Viruses

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The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage.

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Alternate receptor usage of neuropilin-1 and glucose transporter protein 1 by the human T cell leukemia virus type 1

Cited by 22 publications

References 39 publications

Current concepts regarding the HTLV-1 receptor complex

Current concepts regarding the HTLV-1 receptor complex

Human T-Cell Leukemia Virus Type 1 Tax-Deregulated Autophagy Pathway and c-FLIP Expression Contribute to Resistance against Death Receptor-Mediated Apoptosis

Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

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