2005
DOI: 10.1089/thy.2005.15.943
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Alternate Pathways of Thyroid Hormone Metabolism

Abstract: The major thyroid hormone (TH) secreted by the thyroid gland is thyroxine (T(4)). Triiodothyronine (T(3)), formed chiefly by deiodination of T(4), is the active hormone at the nuclear receptor, and it is generally accepted that deiodination is the major pathway regulating T(3) bioavailability in mammalian tissues. The alternate pathways, sulfation and glucuronidation of the phenolic hydroxyl group of iodothyronines, the oxidative deamination and decarboxylation of the alanine side chain to form iodothyroacetic… Show more

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Cited by 187 publications
(187 citation statements)
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“…4) and were shown to be active: for instance TRIAC, the T 3 deaminated derivative displays strong themogenic effects and has a higher affinity for TR than T 3 . This compound is less stable than T 3 , but its production represents 14% of T 3 metabolism (Moreno et al, 2008;Wu et al, 2005). Nonetheless, the general biological action of those TH derivatives remains vague (Wu et al, 2005).…”
Section: Diversity Of Thyroactive Compoundsmentioning
confidence: 99%
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“…4) and were shown to be active: for instance TRIAC, the T 3 deaminated derivative displays strong themogenic effects and has a higher affinity for TR than T 3 . This compound is less stable than T 3 , but its production represents 14% of T 3 metabolism (Moreno et al, 2008;Wu et al, 2005). Nonetheless, the general biological action of those TH derivatives remains vague (Wu et al, 2005).…”
Section: Diversity Of Thyroactive Compoundsmentioning
confidence: 99%
“…This compound is less stable than T 3 , but its production represents 14% of T 3 metabolism (Moreno et al, 2008;Wu et al, 2005). Nonetheless, the general biological action of those TH derivatives remains vague (Wu et al, 2005). In other chordates, no exhaustive repertoire is available.…”
Section: Diversity Of Thyroactive Compoundsmentioning
confidence: 99%
See 2 more Smart Citations
“…Oxidative deamination and decarboxylation occurring in the kidney, liver and muscle, form acid metabolites, which maintain a certain biological activity, but do not contribute to the hormone action in euthyroid subjects because they are produced in very small amounts (Greenspan, 2001). Decarboxylated derivatives of iodothyronines, such as monoiodothyronamine and thyronamine, actually represent a very interesting field of investigation, because they may have some biological actions, even different from those of TH (Wu et al, 2005).…”
Section: Introductionmentioning
confidence: 99%