Alternate pathways in the desaturation and chain elongation of linolenic acid, 18:3(n-3), in cultured glioma cells.

Cook, Harold W.; Byers, David M.; Palmer, Felicity B.; Spence, Matthew W.; Rakoff, Henry; Duval, S. M.; Emken, E. A.

doi:10.1016/s0022-2275(20)41956-x

Cited by 48 publications

(1 citation statement)

References 37 publications

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“…A further marked expression of FAD-2 identified within mammalian cells is ∆8desaturase (D8D). This enzyme establishes an autonomous pathway distinct from D6D, introducing an additional double bond to substrates like ALA, LA, and their elongated polyunsaturated fatty acids, resulting in the formation of very long-chain polyunsaturated fatty acids [375,376]. For instance, the emergence of D8D was observed when DGLA and eicosatetraenoic acid were derived from eicosadienoic acid (C20:2 n6) and eicosatrienoic acid (C20:3 n3), respectively [377].…”

Section: Desaturation Of Fatty Acidsmentioning

confidence: 99%

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

Ali,

Szabó

2023

IJMS

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Biological membranes, primarily composed of lipids, envelop each living cell. The intricate composition and organization of membrane lipids, including the variety of fatty acids they encompass, serve a dynamic role in sustaining cellular structural integrity and functionality. Typically, modifications in lipid composition coincide with consequential alterations in universally significant signaling pathways. Exploring the various fatty acids, which serve as the foundational building blocks of membrane lipids, provides crucial insights into the underlying mechanisms governing a myriad of cellular processes, such as membrane fluidity, protein trafficking, signal transduction, intercellular communication, and the etiology of certain metabolic disorders. Furthermore, comprehending how alterations in the lipid composition, especially concerning the fatty acid profile, either contribute to or prevent the onset of pathological conditions stands as a compelling area of research. Hence, this review aims to meticulously introduce the intricacies of membrane lipids and their constituent fatty acids in a healthy organism, thereby illuminating their remarkable diversity and profound influence on cellular function. Furthermore, this review aspires to highlight some potential therapeutic targets for various pathological conditions that may be ameliorated through dietary fatty acid supplements. The initial section of this review expounds on the eukaryotic biomembranes and their complex lipids. Subsequent sections provide insights into the synthesis, membrane incorporation, and distribution of fatty acids across various fractions of membrane lipids. The last section highlights the functional significance of membrane-associated fatty acids and their innate capacity to shape the various cellular physiological responses.

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Section: Desaturation Of Fatty Acidsmentioning

confidence: 99%